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- Table of Contents
Facts about Fibroblast growth factor 4.
.
Human | |
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Gene Name: | FGF4 |
Uniprot: | P08620 |
Entrez: | 2249 |
Belongs to: |
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heparin-binding growth factors family |
FGF4; FGF-4; fibroblast growth factor 4; HBGF-4; HBGF-4Transforming protein KS3; heparin secretory transforming protein 1; Heparin secretory-transforming protein 1; Heparin-binding growth factor 4; HST-1; HST-1HSTF-1; HSTF1fibroblast growth factor 4 splice isoform; HSTFGF-4; human stomach cancer, transforming factor from FGF-related oncogene; kaposi sarcoma oncogene; KFGF; K-FGF; KS3; oncogene HST
Mass (kDA):
22.048 kDA
Human | |
---|---|
Location: | 11q13.3 |
Sequence: | 11; NC_000011.10 (69771022..69775341, complement) |
Secreted.
Boster Bio is a smart option for your research. Apart from providing a complete guide with tips and tricks as well as optimization guides, Boster Bio can assist you in making educated decisions and get better results. While every researcher will encounter difficulties with troubleshooting issues, using the correct controls can eliminate many of the causes of error. These guides will help identify and fix the issues that are causing problems during your research. In the end, your experiments will be more precise and efficient.
There are many options for optimizing for the FGF4 marker. It can be confusing to choose which is most suitable for your experiments. Luckily, Boster Bio has troubleshooting guides for common mistakes and their solutions. These guides will assist you in executing the perfect experiment every time. Boster offers a variety of other suggestions and a group of researchers who can help you make the most out of your experiments.
If you're not familiar with flow cytometry and wonder how to optimize your experiments. If you're unsure of how to use your Boster Bio flow cytometer, a troubleshooting manual can help. This user guide outlines the procedures needed to conduct a variety flow cytometry experiments. These manuals can be used as quick reference guides and reference guides for the different methods. The binding of an antibody against an antigen on a surface can trigger cells and alter intracellular signalling protein expression. A guide to improving the performance of flow-cytometry instruments offers tips for optimizing the performance of flow-cytometry instruments.
BosterBio's guide for immunohistochemistry, for example, provides the best method for achieving optimal staining. It also provides detailed troubleshooting advice and directions on how to prepare different types of preserved tissues. A comprehensive guide to various types of preparation for tissue will help you maximize your workflow efficiency. The guide also provides most efficient methods to prepare various types of tissue that can be preserved for IHC.
To understand the relationship between BMP antagonists and FGF4 signaling, we first must understand the function of both proteins. BMP receptors (BMPs2, 4, and 7) are essential for full activation of the FGF signaling pathway. The FGF receptors are essential to epithelial cell growth.
Of the many functions BMP has in the body, FGFs are one of its most important. Both ligands act antagonically to regulate cell differentiation and growth. In in vitro, BMPs have been shown to stimulate lens fiber cells proliferation and differentiation. They also affect the expression of genes that are downstream of the BMP signaling pathway. For instance, BRE-Luc is driven by BREs in the mouse Id1 gene. BRE-Luc expression in multiple cell types has been extensively examined. It has been demonstrated to be directly connected to Smad signaling.
In a recent research, DCDMLs were grown at a low density and stimulated by 10 ng/ml BMP4 along with 20 ng/ml of FGF2 and 20 ng/ml FGF9 , in a single well. The incubation of DCDMLs with these two substances resulted in a reduction of BMPs and an increase of FGF4. DCDMLs are , therefore, a vital component of a disease.
A recent study revealed that DCDMLs when co-transfected with DCR1 promoter-EGFP reporter, stimulated DCR1-aA promoter-GFFP expression by 3.4-fold. BMP4 + PD173074 did not affect DCR1-aA-promoter-EGFP expression. These results are not surprising considering that DCDMLs may be sensitive to FGF receptors.
The effects of TPA on the expression of BRE-Luc were similar to the effects of BMPs. Additionally, TPA induces the expression of SBE4-Luc, a TGFb-specific reporter. These two drugs could improve clinical trials. Also, BMP antagonists and FGF4 Marker are essential in advancing research in this field. They may not work for all patients.
In addition to preventing BMP4/7 signaling, noggin and dorsomorphin also block its expression. In a previous study DCDMLs were transfected using a BRE–Luc reporter , and then cultured for 2 days without any other treatment. Five ng/ml BMP4 was added and 10 ng/ml BMP6 were added. Noggin was used to stop BMP signaling in DCDMLs.
PMID: 18192227 by Mayshar Y., et al. Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self- renewal.
PMID: 2959959 by Yoshida T., et al. Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.
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