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- Table of Contents
GBP1 Antibodies
AND GBP1 ELISA kits, GBP1 Proteins
Many biological assays use antibodies to detect GBP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GBP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GBP1 antibodies...
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GBP1 Infographic by Boster Bio
All GBP1 Products
Product
Figures
Specificity
Applications
Price
Human
WB
$370
Cat # PA1550
100 μg/vial
Cat # PA1550
100 μg/vial
Human
Flow Cytometry, IF, IHC, WB
$523
Cat # M03067
100 µl
Cat # M03067
100 µl
Human, Mouse, Rat
ELISA, Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # A03067-1
100 μg/vial
Cat # A03067-1
100 μg/vial
GBP1 Overview
Facts about Guanylate-binding protein 1.
Guanylate-binding protein 1 (GBP1)
Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus.
Promote oxidative killing and deliver antimicrobial peptides into autophagolysosomes, providing broad host protection against different pathogen classes. .
Gene Information
| Human | |
|---|---|
| Gene Name: | GBP1 |
| Uniprot: | P32455 |
| Entrez: | 2633 |
Family
| Belongs to: |
|---|
| TRAFAC class dynamin-like GTPase superfamily |
Alternative Names
GBP-1; GTP-binding protein 1; Guanine nucleotide-binding protein 1; guanylate binding protein 1, interferon-inducible; guanylate binding protein 1, interferon-inducible, 67kDa; huGBP-1; interferon-induced guanylate-binding protein 1
Molecular Weight
Mass (kDA):
67.931 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p22.2 |
| Sequence: | 1; NC_000001.11 (89052319..89065208, complement) |
Subcellular Localizations
Cytoplasm. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cell membrane. Secreted. Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor.
Diseases
- Inflammation
- Neoplasms
- Tumor Angiogenesis
- Malignant Neoplasms
- Glioma
- Pathologic Neovascularization
- Adenocarcinoma
- Carcinoma
- Virus Diseases
- Cell Invasion
- Glioblastoma
- Vesicular Stomatitis
- Stomatitis
Pathways
- Angiogenesis
- Cell Proliferation
- Localization
- Immune Response
- Endothelial Cell Proliferation
- Cell Death
- Transport
- Response To Interferon-gamma
- Cell Growth
- Pathogenesis
- Cell Migration
- Virulence
- Myelination
PTMs
- Phosphorylation
- Prenylation
- Farnesylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GBP1
bosterbio.com/bosterbio-gene-info-cards/GBP1
References
PMID: 1715024 by Cheng Y.-S.E., et al. Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP.
PMID: 8830800 by Nantais D.E., et al. Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1.