GGCX Antibodies

AND GGCX ELISA kits, GGCX Proteins

Many biological assays use antibodies to detect GGCX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with GGCX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop GGCX antibodies...

We validate the specificity of these antibodies to GGCX by testing them on tissues known to express GGCX positively and negatively. Browse below to find the GGCX antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for GGCX? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the GGCX Western Blot Guide

Designing an IHC experiment for GGCX? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the GGCX IHC Guide

GGCX Infographic by Boster Bio

All GGCX Products

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Figures

Specificity

Applications

Price

Anti-GGCX Antibody Picoband®

Western blot analysis of GGCX using anti-GGCX antibody (A02643-1)

IHC analysis of GGCX using anti-GGCX antibody (A02643-1)

IF analysis of GGCX using anti-GGCX antibody (A02643-1)

Human, Mouse

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A02643-1
100 μg/vial

GGCX (NM_000821) Human Over-expression Lysate

Human

$628
Cat # LS002677
20 µg, 100 µg

GGCX Overview

Facts about Vitamin K-dependent gamma-carboxylase.

GGCX 3D structure. Source: alphafold

Vitamin K-dependent gamma-carboxylase (GGCX)

Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. .

Gene Information

Human
Gene Name:	GGCX
Uniprot:	P38435
Entrez:	2677

Family

Belongs to:

vitamin K-dependent gamma-carboxylase family

Alternative Names

EC 4.1.1.90; gamma-glutamyl carboxylaseFLJ26629; GC; Peptidyl-glutamate 4-carboxylase; Vitamin K gamma glutamyl carboxylase; vitamin K-dependent gamma-carboxylase; VKCFD1

Molecular Weight

Mass (kDA):
87.561 kDA

Genomic Context


Human

Location:	2p11.2
Sequence:	2; NC_000002.12 (85544720..85561527, complement)

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Pseudoxanthoma Elasticum
Hemorrhage
Thromboembolism
Blood Coagulation Disorders
Coagulation Factor Deficiency
Venous Thrombosis
Thrombosis
Cholangiocarcinoma
Dysequilibrium Syndrome
Cerebrovascular Accident
Cutis Laxa
Multisystem Disorder
Osteoporosis

Urolithiasis
Bleeding Tendency
Vitamin K Deficiency
Ischemic Stroke
Nephrolithiasis, Calcium Oxalate
Coagulation Protein Disorders
Calcinosis

Pathways

Coagulation
Blood Coagulation
Translation
Protein Carboxylation
Response To Vitamin K
Bone Development

Response To Vitamin

PTMs

Carboxylation
Gamma-carboxylation

Phosphorylation
Reduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/GGCX

References

PMID: 1749935 by Wu S.-M., et al. Cloning and expression of the cDNA for human gamma-glutamyl carboxylase.

PMID: 9166845 by Wu S.-M., et al. Genomic sequence and transcription start site for the human gamma- glutamyl carboxylase.