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- Table of Contents
Facts about Beta-adrenergic receptor kinase 1.
Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378).
Human | |
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Gene Name: | GRK2 |
Uniprot: | P25098 |
Entrez: | 156 |
Belongs to: |
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protein kinase superfamily |
ADRBK1; adrenergic, beta, receptor kinase 1; BARK; BARK1; BARK1beta-ARK-1; Beta-ARK1; Beta-ARK-1; EC 2.7.11; EC 2.7.11.15; FLJ16718; G-protein coupled receptor kinase 2; GRK2; GRK2beta-adrenergic receptor kinase 1
Mass (kDA):
79.574 kDA
Human | |
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Location: | 11q13.2 |
Sequence: | 11; NC_000011.10 (67266420..67286556) |
Expressed in peripheral blood leukocytes.
Cytoplasm. Cell membrane.
PMID: 2037065 by Benovic J.L., et al. cDNA cloning and chromosomal localization of the human beta- adrenergic receptor kinase.
PMID: 1339451 by Chuang T.T., et al. High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.