HCN2 Antibodies

AND HCN2 ELISA kits, HCN2 Proteins

Many biological assays use antibodies to detect HCN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with HCN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop HCN2 antibodies...

We validate the specificity of these antibodies to HCN2 by testing them on tissues known to express HCN2 positively and negatively. Browse below to find the HCN2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for HCN2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the HCN2 Western Blot Guide

HCN2 Infographic by Boster Bio

All HCN2 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-HCN2 Antibody Picoband®

3 Citations

IHC analysis of HCN2 using anti-HCN2 antibody (A02804)

Western blot analysis of HCN2 using anti-HCN2 antibody (A02804)

Human, Mouse, Rat

IHC, WB

$370
Cat # A02804
100 μg/vial

Anti-Hcn2 Antibody Picoband®

Western blot analysis of Hcn2 using anti-Hcn2 antibody (A02804-1)

IHC analysis of Hcn2 using anti-Hcn2 antibody (A02804-1)

Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A02804-1
100 µg/vial

HCN2 (NM_001194) Human Over-expression Lysate

Human

$960
Cat # LS000610
20 µg, 100 µg

HCN2 Overview

Facts about Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2.

HCN2 3D structure. Source: alphafold

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (HCN2)

Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih).

Can also transport ammonium in the distal nephron. Produces a large instantaneous current.

Gene Information

Human
Gene Name:	HCN2
Uniprot:	Q9UL51
Entrez:	610

Family

Belongs to:

potassium channel HCN family

Alternative Names

BCNG2; BCNG-2; brain cyclic nucleotide gated channel 2; brain cyclic nucleotide-gated channel 2; HAC-1; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2

Molecular Weight

Mass (kDA):
96.95 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (589881..617159)

Tissue Specificity

Highly expressed throughout the brain. Detected at low levels in heart.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Epilepsy
Cardiac Arrhythmia
Nervousness
Pain
Hypertrophy
Bradycardia
Heart Failure
Channelopathies
Febrile Convulsions
Depressive Disorder
Inflammation
Complete Atrioventricular Block

Neuralgia
Absence Epilepsy
Atrioventricular Block
Epilepsy, Temporal Lobe
Pituitary Diseases
Globus Hystericus
Long Qt Syndrome

Interacting Proteins

PSEN1

Pathways

Localization
Membrane Hyperpolarization
Reverse Transcription
Glycosylation
Synaptic Transmission
Cardiac Conduction
Cell Death
Secretion
Transport
Aging
Pathogenesis
Response To Camp
Reflex

Cognition
Insulin Secretion
Hypersensitivity
M Phase
Nuclear Export
Sensitization
Cell Cycle

PTMs

Phosphorylation
Glycosylation

Dephosphorylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/HCN2

References

PMID: 10524219 by Vaccari T., et al. The human gene coding for HCN2, a pacemaker channel of the heart.

PMID: 10228147 by Ludwig A., et al. Two pacemaker channels from human heart with profoundly different activation kinetics.

2 Publications of Boster HCN2 Antibodies & ELISA Kits

PubMed ID: 10.3892/mmr.2011.455, Spironolactone diminishes spontaneous ventricular premature beats by reducing HC...
PubMed ID: 10.1074/jbc.RA120.013281, The HCN domain is required for HCN channel cell-surface expression and couples v...

*More publications can be found for each product on its corresponding product page