Huntingtin-interacting protein 1-related protein (HIP1R)

Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (through ENTH domain).

May act through the ENTH domain name to promote cell survival by stabilizing receptor tyrosine kinases after ligand-induced endocytosis. .