Serine protease HTRA3 Antibodies

AND Htra3 ELISA kits, Serine protease HTRA3 Proteins

Many biological assays use antibodies to detect Serine protease HTRA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Serine protease HTRA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Serine protease HTRA3 antibodies...

We validate the specificity of these antibodies to Serine protease HTRA3 by testing them on tissues known to express Htra3 positively and negatively. Browse below to find the Htra3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Htra3 Infographic by Boster Bio

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Anti-HtrA3 Antibody Picoband®

3 Q&As

Western blot analysis of HtrA3 using anti-HtrA3 antibody (A05478)

Human

$370
Cat # A05478
100 μg/vial

Htra3 Overview

Facts about Serine protease HTRA3.

Serine protease HTRA3 (Htra3)

Serine protease that cleaves beta-casein/CSN2 in addition to several extracellular matrix (ECM) proteoglycans like decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins maybe indirectly by degradation of these ECM proteoglycans (PubMed:15206957).

May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo.

Gene Information

Mouse
Gene Name:	Htra3
Uniprot:	Q9D236
Entrez:	78558

Family

Belongs to:

peptidase S1C family

Alternative Names

EC 3.4.21; EC 3.4.21.-; EC 3.4.21.108; High-temperature requirement factor A3; HTRA 3; HtrA serine peptidase 3; HTRA3; Pregnancy-related serine protease; probable serine protease HTRA3; Prsp; serine protease HTRA3; Tasp

Molecular Weight

Mass (kDA):
49.149 kDA

Genomic Context


Mouse

Location:	5\|5 B3
Sequence:	5;

Tissue Specificity

Highest level of isoform 1 in maternal part of the placenta, moderate level in heart, testis and ovary, low level in muscle and lung. High expression found in granulosa cells of the ovary. Expressed in bone matrix, particularly in articular chondrocytes. Very low level of isoform 2 expressed in placenta. Expressed in the bone matrix, particularly in articular chondrocytes.

Diseases

Malignant Neoplasms
Neoplasms
Endometrial Polyp
Malignant Paraganglionic Neoplasm
Pre-eclampsia
Carcinoma
Malignant Neoplasm Of Ovary
Ovarian Neoplasm
Endometrial Neoplasms
Malignant Neoplasm Of Lung
Cell Invasion
Benign Neoplasm

Lung Neoplasms
Arthritis
Endometrial Carcinoma
Pregnancy Complications
Asthenia
Atresia
Melanoma

Pathways

Localization
Cellular Localization
Cell Death
Secretion
Cell Migration
Programmed Cell Death
Methylation
Decidualization
Cell Growth
Luteinization
Transport
Gene Silencing
Fertilization

Virulence
Sexual Reproduction
Regulation Of Programmed Cell Death
Translation
Embryo Implantation
Cell Cycle
Cell Motility

PTMs

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Htra3

References

PMID: 12728021 by Nie G.Y., et al. A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation.

PMID: 15206957 by Tocharus J., et al. Developmentally regulated expression of mouse HtrA3 and its role as an inhibitor of TGF-beta signaling.