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- Table of Contents
IMPDH1 Antibodies
AND IMPDH1 ELISA kits, IMPDH1 Proteins
Many biological assays use antibodies to detect IMPDH1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IMPDH1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IMPDH1 antibodies...
Designing a Western blot for IMPDH1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the IMPDH1 Western Blot GuideIMPDH1 Infographic by Boster Bio
All IMPDH1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03791-1
100 μg/vial
Cat # A03791-1
100 μg/vial
IMPDH1 Overview
Facts about Inosine-5'-monophosphate dehydrogenase 1.
Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and consequently has an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding action and could play a role in RNA and/or DNA metabolism.
It might also have a role in the development of malignancy and the growth progression of some tumors. .
Gene Information
| Human | |
|---|---|
| Gene Name: | IMPDH1 |
| Uniprot: | P20839 |
| Entrez: | 3614 |
Family
| Belongs to: |
|---|
| IMPDH/GMPR family |
Alternative Names
DKFZp781N0678; EC 1.1.1.205; IMP (inosine 5'-monophosphate) dehydrogenase 1; IMP (inosine monophosphate) dehydrogenase 1; IMP Dehydrogenase 1; IMPD 1; IMPD; IMPD1; IMPDH 1; IMPDH1; IMPDH-I; inosine-5'-monophosphate dehydrogenase 1; LCA11; LCA11RP10; retinitis pigmentosa 10 (autosomal dominant); RP10; sWSS2608
Molecular Weight
Mass (kDA):
55.406 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q32.1 |
| Sequence: | 7; NC_000007.14 (128392277..128409989, complement) |
Tissue Specificity
IMP type I is the main species in normal leukocytes and type II predominates over type I in the tumor.
Subcellular Localizations
Cytoplasm. Nucleus.
Diseases
- Retinitis Pigmentosa
- Retinal Degeneration
- Retinal Diseases
- Blind Vision
- Amaurosis
- Leber Congenital Amaurosis
- Abnormal Degeneration
- Decreased Immunologic Activity [pe]
- Diarrhea
- Retinal Dystrophies
- Malignant Neoplasms
Pathways
- Transport
- Cell Proliferation
- Pathogenesis
- Localization
- Translation
- Cell Death
- Cell Growth
- Phototransduction
- Cell Activation
- Induction Of Apoptosis
- T Cell Activation
- Brain Development
- Glycosylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IMPDH1
bosterbio.com/bosterbio-gene-info-cards/IMPDH1
References
PMID: 1969416 by Natsumeda Y., et al. Two distinct cDNAs for human IMP dehydrogenase.
PMID: 7903306 by Carr S.F., et al. Characterization of human type I and type II IMP dehydrogenases.