Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism.

It may also have a role in the development of malignancy and the growth progression of some tumors. .