IQCB1 Antibodies

AND IQCB1 ELISA kits, IQCB1 Proteins

Many biological assays use antibodies to detect IQCB1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IQCB1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IQCB1 antibodies...

We validate the specificity of these antibodies to IQCB1 by testing them on tissues known to express IQCB1 positively and negatively. Browse below to find the IQCB1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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IQCB1 Infographic by Boster Bio

All IQCB1 Products

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Anti-Nephrocystin-5 IQCB1 Antibody

3 Q&As

Western Blot analysis of SH-SY5Y cells using Nephrocystin-5 Polyclonal Antibody diluted at 1:500

Western blot analysis of lysates from K562 cells, using IQCB1 Antibody

Western blot analysis of the lysates from HepG2 cells using IQCB1 antibody

Human, Mouse

ELISA, IF, IHC, WB

$399
Cat # A07108
100μl

Anti-Nephrocystin-5 (R467) IQCB1 Antibody

Western blot (WB) analysis of Nephrocystin-5 (R467) pAb at 1:1000 dilution
Lane1:The Kidney tissue lysate of Mouse(5ug)
Lane2:The Ovary tissue lysate of Rat(40ug)
Lane3:HCT116 whole cell lysate(40ug)

Immunohistochemistry (IHC) analyzes of Nephrocystin-5 (R467) pAb in paraffin-embedded human colon carcinoma tissue

Human, Mouse, Rat

IHC, WB

$405
Cat # A07108-1
100ul

IQCB1 Overview

Facts about IQ calmodulin-binding motif-containing protein 1.

IQCB1 3D structure. Source: alphafold

IQ calmodulin-binding motif-containing protein 1 (IQCB1)

Involved in ciliogenesis.
The function in an early step in cilia formation is dependent upon its association with CEP290/NPHP6 (PubMed:21565611, PubMed:23446637).

Involved in regulation of the BBSome complex integrity, especially for existence of BBS2 and BBS5 in the complex, and in ciliary targeting of selected BBSome cargos. May play a role in controlling entry of the BBSome complex to cilia possibly implicating CEP290/NPHP6 (PubMed:25552655).

Gene Information

Human
Gene Name:	IQCB1
Uniprot:	Q15051
Entrez:	9657

Family

Belongs to:

No superfamily

Alternative Names

IQ calmodulin-binding motif containing 1; IQ motif containing B1; KIAA0036nephrocystin 5; Nephrocystin-5; NPHP5IQ calmodulin-binding motif-containing protein 1; p53 and DNA damage-regulated IQ motif protein; PIQ; SLSN5

Molecular Weight

Mass (kDA):
68.929 kDA

Genomic Context


Human

Location:	3q13.33\|3q21.1
Sequence:	3; NC_000003.12 (121769761..121835079, complement)

Tissue Specificity

Ubiquitously expressed in fetal and adult tissues. Localized to the outer segments and connecting cilia of photoreceptor cells. Up-regulated in a number of primary colorectal and gastric tumors.

Subcellular Localizations

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Localization to the centrosome depends on the interaction with CEP290/NPHP6.

Diseases

Nephronophthisis
Kidney Diseases
Cystic Kidney Diseases
Amaurosis
Retinitis Pigmentosa
Leber Congenital Amaurosis
Renal Dysplasia And Retinal Aplasia (disorder)
Retinal Degeneration
Kidney Failure, Chronic
Kidney Failure
Optic Atrophies, Hereditary
Situs Inversus

Chronic Eosinophilic Leukemia
Blind Vision
Streptococcal Lymphadenitis Of Swine
Congenital Cerebellar Hypoplasia
Stomach Neoplasms
Hydrocephalus, Normal Pressure

Interacting Proteins

BBS1
BBS2
BBS4
BBS5
BBS7

BBS9
CEP290
TTC8

Pathways

Pathogenesis
Viral Replication

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IQCB1

References

PMID: 16322217 by Luo X., et al. Cloning and characterization of a p53 and DNA damage down-regulated gene PIQ that codes for a novel calmodulin-binding IQ motif protein and is up-regulated in gastrointestinal cancers.

PMID: 15723066 by Otto E.A., et al. Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior- Loken syndrome and interacts with RPGR and calmodulin.