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IRF8 Antibodies
AND IRF8 ELISA kits, IRF8 Proteins
Many biological assays use antibodies to detect IRF8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with IRF8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop IRF8 antibodies...
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IRF8 Infographic by Boster Bio
All IRF8 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PA2209
100 μg/vial
Cat # PA2209
100 μg/vial
Human, Mouse
Flow Cytometry, IP, IF, ICC, WB
$370
Cat # M00638
100 μl/vial
Cat # M00638
100 μl/vial
IRF8 Overview
Facts about Interferon regulatory factor 8.
Interferon regulatory factor 8 (IRF8)
Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)).
Plays a negative regulatory function in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, resulting in recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | IRF8 |
| Uniprot: | Q02556 |
| Entrez: | 3394 |
Family
| Belongs to: |
|---|
| IRF family |
Alternative Names
ICSBP1; ICSBPH-ICSBP; interferon consensus sequence binding protein 1; Interferon consensus sequence-binding protein; interferon regulatory factor 8; IRF8; IRF-8ICSBP1
Molecular Weight
Mass (kDA):
48.356 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 16q24.1 |
| Sequence: | 16; NC_000016.10 (85899162..85922609) |
Tissue Specificity
Predominantly expressed in lymphoid tissues.
Subcellular Localizations
Nucleus. Cytoplasm. In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction.
Diseases
- Leukemia
- Myeloid Leukemia
- Neoplasms
- Inflammation
- Malignant Neoplasms
- Leukemia, Myelocytic, Acute
- Myeloid Leukemia, Chronic
- Sclerosis
- Multiple Sclerosis
- Lupus Erythematosus, Systemic
- Autoimmune Reaction
- Immunologic Deficiency Syndromes
- Autoimmune Diseases
Interacting Proteins
- IRF6
Pathways
- Cell Differentiation
- Cell Development
- Methylation
- Pathogenesis
- Dna Methylation
- Cell Cycle
- Immune Response
- Hypersensitivity
- Demethylation
- Cell Maturation
- B Cell Differentiation
- Osteoclast Differentiation
- Cytokine Production
PTMs
- Methylation
- Phosphorylation
- Demethylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/IRF8
bosterbio.com/bosterbio-gene-info-cards/IRF8
References
PMID: 1460054 by Weisz A., et al. Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.
PMID: 10991940 by Cohen H., et al. Interaction between interferon consensus sequence-binding protein and COP9/signalosome subunit CSN2 (Trip15). A possible link between interferon regulatory factor signaling and the COP9/signalosome.