MRPL58 Antibodies

AND MRPL58 ELISA kits, MRPL58 Proteins

Many biological assays use antibodies to detect MRPL58, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with MRPL58 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop MRPL58 antibodies...

We validate the specificity of these antibodies to MRPL58 by testing them on tissues known to express MRPL58 positively and negatively. Browse below to find the MRPL58 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing an IHC experiment for MRPL58? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the MRPL58 IHC Guide

MRPL58 Infographic by Boster Bio

All MRPL58 Products

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Specificity

Applications

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Anti-ICT1 Antibody (C-term)

ICT1 Antibody (C-term) western blot analysis in Hela,Jurkat,U251,MDA-MB453,NCI-H292,K562,ZR-75-1 cell line lysates (35ug/lane)

Immunohistochemical analysis of paraffin-embedded H

Human

IHC-P, WB

$299
Cat # A31846-1
80 µl

ICT1 (MRPL58) (NM_001545) Human Over-expression Lysate

Human

$628
Cat # LS003396
20 µg, 100 µg

Anti-ICT1 MRPL58 Antibody

Western blot analysis of extracts of various cell lines, using ICT1 antibody at 1:1000 dilution

Human, Mouse, Rat

IHC, WB

$405
Cat # A31846
100ul

ICT1 (MRPL58) (NM_001545) Human Recombinant Protein

Coomassie blue staining of purified MRPL58 protein

$1249
Cat # PROTQ14197
20 µg

MRPL58 Overview

Facts about Peptidyl-tRNA hydrolase ICT1, mitochondrial.

MRPL58 3D structure. Source: alphafold

Peptidyl-tRNA hydrolase ICT1, mitochondrial (MRPL58)

Essential peptidyl-tRNA hydrolase part of the mitochondrial large ribosomal subunit. Acts as a codon-independent translation release factor that has lost all stop codon specificity and directs the termination of translation in mitochondrion, possibly in case of abortive elongation.

May be involved in the hydrolysis of peptidyl-tRNAs that have been prematurely terminated and thus in the recycling of stalled mitochondrial ribosomes. .

Gene Information

Human
Gene Name:	MRPL58
Uniprot:	Q14197
Entrez:	3396

Family

Belongs to:

prokaryotic/mitochondrial release factor family

Alternative Names

Digestion substraction 1; DS-1DS1; EC 3.1.1.29; Immature colon carcinoma transcript 1 protein; immature colon carcinoma transcript 1; peptidyl-tRNA hydrolase ICT1, mitochondrial

Molecular Weight

Mass (kDA):
23.63 kDA

Genomic Context


Human

Location:	17q25.1
Sequence:	17; NC_000017.11 (75012670..75021261)

Tissue Specificity

Down-regulated during the in vitro differentiation of HT29-D4 colon carcinoma cells.

Subcellular Localizations

Mitochondrion.

Diseases

Malignant Tumor Of Colon
Carcinoma
Neoplasms
Triglyceride Storage Disease With Ichthyosis
Ophthalmoplegia
Optic Atrophy
Cell Transformation, Neoplastic
Hereditary Diseases
Colonic Neoplasms
Ichthyoses
Atrophy
Malignant Paraganglionic Neoplasm

Malaria, Falciparum
Leigh Disease
Fibrolamellar Carcinoma
Malignant Neoplasms
Colorectal Neoplasms
Malaria
Colorectal Cancer

Pathways

Translation
Mitochondrial Translation
Drug Resistance
Cell Proliferation
Asexual Reproduction
Cell Death
Lipid Homeostasis
Cell Differentiation

Lipid Binding
Oxidative Phosphorylation

PTMs

Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MRPL58

References

PMID: 8575443 by van Belzen N., et al. Identification of mRNAs that show modulated expression during colon carcinoma cell differentiation.

PMID: 20186120 by Richter R., et al. A functional peptidyl-tRNA hydrolase, ICT1, has been recruited into the human mitochondrial ribosome.