Integrin alpha-5 (ITGA5)

Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands.

ITGA5:ITGB1 binds to PLA2G2A by means of a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and improved ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 functions as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881).