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- Table of Contents
Protein jagged-1 Antibodies
AND JAG1 ELISA kits, Protein jagged-1 Proteins
Many biological assays use antibodies to detect Protein jagged-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein jagged-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein jagged-1 antibodies...
Designing a Western blot for Protein jagged-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the JAG1 Western Blot GuideDesigning an IHC experiment for Protein jagged-1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the JAG1 IHC GuideJAG1 Infographic by Boster Bio
All JAG1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # M00640-2
100 μl/vial
Cat # M00640-2
100 μl/vial
JAG1 Overview
Facts about Protein jagged-1.
Protein jagged-1 (JAG1)
Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (PubMed:18660822, PubMed:20437614). May be involved in cell-fate decisions during hematopoiesis (PubMed:9462510).
Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | JAG1 |
| Uniprot: | P78504 |
| Entrez: | 182 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
AGS; AHDMGC104644; Alagille syndrome; AWS; CD339 antigen; CD339; HJ1; JAG1; Jagged 1; Jagged1; JAGL1; protein jagged-1
Molecular Weight
Mass (kDA):
133.799 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p12.2 |
| Sequence: | 20; NC_000020.11 (10637684..10673999, complement) |
Tissue Specificity
Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Subcellular Localizations
Membrane; Single-pass type I membrane protein.
Diseases
- Alagille Syndrome
- Malignant Neoplasms
- Neoplasms
- Haploinsufficiency
- Malignant Neoplasm Of Breast
- Congenital Heart Defects
- Tetralogy Of Fallot
- Carcinoma
- Cholestasis
- Stenosis
- Liver Diseases
- Mammary Neoplasms
- Cell Transformation, Neoplastic
Interacting Proteins
- CD46
- NOTCH1
Pathways
- Notch Signaling Pathway
- Cell Differentiation
- Cell Proliferation
- Pathogenesis
- Cell Cycle
- Angiogenesis
- Neurogenesis
- Regeneration
- Lateral Inhibition
- Cell Fate Determination
- Ear Development
- Cell Fate Specification
- Localization
PTMs
- Cleavage
- Methylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAG1
bosterbio.com/bosterbio-gene-info-cards/JAG1
References
PMID: 9268641 by Oda T., et al. Identification and cloning of the human homolog (JAG1) of the rat Jagged1 gene from the Alagille syndrome critical region at 20p12.
PMID: 9207788 by Li L., et al. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1.