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- Table of Contents
JAK2 Antibodies
AND JAK2 ELISA kits, JAK2 Proteins
Many biological assays use antibodies to detect JAK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with JAK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop JAK2 antibodies...
Designing a Western blot for JAK2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the JAK2 Western Blot GuideDesigning an IHC experiment for JAK2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the JAK2 IHC GuideJAK2 Infographic by Boster Bio
All JAK2 Products
Product
Figures
Specificity
Applications
Price
Anti-JAK2 Monoclonal Antibody
12 Citations
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M00027
100 μl
Cat # M00027
100 μl
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # MP00027
100 μl
Cat # MP00027
100 μl
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00027-3
20μL, 40μL, 100μL, 200μL
Cat # M00027-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
ELISA
$540
Cat # EKC2080
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2080
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1315
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1315
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2565
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2565
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2441
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2441
1 kit, containing two 96-well plates and all necessary reagents
JAK2 Overview
Facts about Tyrosine-protein kinase JAK2.
Tyrosine-protein kinase JAK2 (JAK2)
Non-receptor tyrosine kinase involved in various processes like cell growth, growth, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity.
In the cytoplasm, plays a pivotal role in signal transduction through its association with type I receptors like growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins (PubMed:7615558). Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins (PubMed:9618263).
Gene Information
| Human | |
|---|---|
| Gene Name: | JAK2 |
| Uniprot: | O60674 |
| Entrez: | 3717 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.10; EC 2.7.10.2; Jak2; JAK-2; Janus kinase 2Janus kinase 2 (a protein tyrosine kinase); JTK10; tyrosine-protein kinase JAK2
Molecular Weight
Mass (kDA):
130.674 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9p24.1 |
| Sequence: | 9; NC_000009.12 (4985086..5129948) |
Tissue Specificity
Ubiquitously expressed throughout most tissues.
Subcellular Localizations
Endomembrane system; Peripheral membrane protein. Cytoplasm. Nucleus.
Diseases
- Janiceps
- Myeloproliferative Disease
- Neoplasms
- Polycythemia Vera
- Leukemia
- Polycythemia
- Thrombocytosis
- Thrombocythemia, Essential
- Primary Myelofibrosis
- Malignant Neoplasms
- Myeloid Leukemia
- Jak2 Gene Mutation
- Thrombosis
Interacting Proteins
- CSF2RB
- IL5RA
- JAK1
- MPL
- NCK1
- PTPN1
- ROCK2
- Slc40a1
- TYK2
Pathways
- Pathogenesis
- Cell Proliferation
- Cell Growth
- Secretion
- Cell Death
- Cell Cycle
- Localization
- Angiogenesis
- Cell Differentiation
- Hypersensitivity
- Transport
- Immune Response
- Induction Of Apoptosis
PTMs
- Phosphorylation
- Dephosphorylation
- Cleavage
- Methylation
- Ubiquitination
- Reduction
- Acetylation
- Oxidation
- Demethylation
- Nitration
Research Areas
- Cell Cycle and Replication
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/JAK2
bosterbio.com/bosterbio-gene-info-cards/JAK2
References
PMID: 9618263 by Saltzman A., et al. Cloning and characterization of human Jak-2 kinase: high mRNA expression in immune cells and muscle tissue.
PMID: 9446644 by Dalal I., et al. Cloning and characterization of the human homolog of mouse Jak2.
3 Publications of Boster JAK2 Antibodies & ELISA Kits
- PubMed ID: -, Zhu L,Liu Y,Wu X,et al.Cerebroprotein hydrolysate-I protects senescence-induced ...
- PubMed ID: 33152901, He J,Zhang W,Di T,Meng J,Qi Y,Li G,Zhang Y,Su H,Yan W.Water extract of sporoderm...
- PubMed ID: 33542641, Zhang Q,Duan HX,Li RL,Sun JY,Liu J,Peng W,Wu CJ,Gao YX. Inducing Apoptosis and S...
*More publications can be found for each product on its corresponding product page