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Facts about Lysozyme C.
Human | |
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Gene Name: | LYZ |
Uniprot: | P61626 |
Entrez: | 4069 |
Belongs to: |
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glycosyl hydrolase 22 family |
EC 3.2.1.17; lysozyme (renal amyloidosis)1,4-beta-N-acetylmuramidase C; lysozyme C; Lysozyme; LZM; renal amyloidosis
Mass (kDA):
16.537 kDA
Human | |
---|---|
Location: | 12q15 |
Sequence: | 12; NC_000012.12 (69348381..69354234) |
Secreted.
The Anti-Lysozyme protein and agent are useful tools for research. But what are their applications? This article will cover the best uses of these products as well the gene/antibody that detects LYZ in samples. This article is applicable to scientists from any country in the world, including the US, UK, and Australia. It will also discuss the different types of LYZ markers on the market.
Many biological assays use antibodies to recognize Lysozyme-4 proteins from a variety. Boster Bio's Lysozyme Enzyme Kit uses rabbit and mouse as models. Boster Bio's Anti Lysozyme enzyme Kit detects this lysozymelike protein using affinity chromatography.
Lysozyme proteins are found in plasma, white cells, and human milk. These proteins are capable of preventing the growth of various bacterial strains. Heritable renal amyloidosis is associated with missense mutations in the LYZ gene. This enzyme also enhances activity of immunoagents. It is also found in egg whites and the cytoplasmicgranules from polymorphonuclear neutrophils.
The lysozyme antibody is capable of staining a variety of cells, including myeloid cells, granulocytes, and monocytes. It is useful in aiding in the classification lymphoproliferative disorder. It also stains plastic-embedded lymphoid tissues and can be used in immunohistochemistry. The Boster Bio Anti-Lysozyme enzyme antibody is available for immunohistochemistry.
According to laboratory studies, macrophages and monoocytes are the main producers of lysozyme in laboratory experiments. The strongest inducer of lysozyme enzyme activity is Lipopolysaccharide. In fact, immunization of adult fish results in a higher circulating level lysozyme. Myeloid cells are also affected by environmental toxins.
Boster Bio Antilyso-like protein 1 LYZL1 antibodies are available for use in ELISA and WB. It reacts with humanly lysozyme C. It was raised against a synthetic peptide of 17 amino acids in LYZL1. In addition to the antibody, a blocking peptide (NPA) is available for purchase separately.
This product has been validated by using positive and non-positive samples. After the last immunization, sera levels reached 1:25,600. The VHH Phage Display Library was created and screened. It contained 2.8 x105 individual Clones. The phage ELISA was used for analysis. The enrichment of antigen-specific clones in the library was also assessed.
Lysozyme (derived from the LYZ Gene) is an enzyme that cleaves Beta glycosidic linking. It is found in human milk, white blood cell, and plasma and has antibacterial activity for a variety of bacteria. Some cancers lead to the overproduction lysozyme. Patients with high levels of lysozyme can develop low blood potassium or kidney failure. However, their symptoms may improve after they have received the appropriate treatment for their primary malignancy.
RNases and lysozymes are two different proteins that inhibit HIV-1. Anti-lysozyme agents are able to block both the RNA as well as the protein components of HIV-1. They can also be used to provide additional treatment options for HIV-1 infection. In addition to lysozyme inhibitors, antiviral drugs should be composed of both RNases and lysozymes.
Their Picoband(tm), which includes the Boster Bio Anti-Lysozyme/LYZ anti-lysozyme/LYZ, is available. It reacts with Human Lysozymes, Rat Lysozymes, and Mouse Lysozymes. The amount of antibody that reacts to Lysozyme from humans and rats determines the product's effectiveness. Boster Bio Anti-Lysozyme/LYZ Anti-Lysozyme/LYZ can be used for studies on lysozyme activity in cell culture.
Lysozyme was originally discovered by Fleming. Fleming's initial culture of the bacteria showed that it caused the organisms to break down. He began to study the enzyme and discovered that it had antibacterial activity. He also discovered that it is more efficient against harmless airborne bacteria. However, Fleming's experiments failed to identify how to increase the concentration of lysozyme to improve its antibacterial activity.
Lysozyme is an extremely valuable commodity that is difficult to produce in large quantities. High antibacterial activity has been demonstrated by the commercial human lysozyme GS115. This agent is GRAS for food production and drug manufacturing. This is a highly-desired antibacterial agent in boster biology. It is used in both the pharmaceutical and food industry, but also in human lysozyme manufacturing.
There are many biological functions for Lyz, including antiviral and transporting drugs. Numerous spectroscopic approaches have been used in order to identify the binding between Nos and Lyz. UV-visible fluorescence spectroscopy, circular dichroism spectroscopy, and molecular docking have all been used to understand the binding mechanism. These methods also allow researchers to calculate the free energy of the interaction and determine the stability of the binding.
The LYZ genetic marker is an important tool for many research applications. The gene is highly conserved between humans and other species, and its use in detecting cancer cells can be extremely useful. The F57I gene mutation results in an altered Lysozyme Aggregation process, which causes cytotoxic species. F57I cells are prevented from dying by the SAP. This prevents the formation of toxic structures due to this mutation.
Boster Bio Anti-Lysozyme-like Antibody 1 LYZL1 Antibody, catalog # A15700, has been validated to be used in WB as well as ELISA tests against Human. The synthetic peptide of 17 amino-acids is used to generate the antibody. It binds with the first 50 LYZL1 residues. To avoid cross-reactivity, a blocking peptide is available.
PMID: 2971592 by Castanon M.J., et al. Cloning of human lysozyme gene and expression in the yeast Saccharomyces cerevisiae.
PMID: 3413092 by Chung L.P., et al. Cloning the human lysozyme cDNA: inverted Alu repeat in the mRNA and in situ hybridization for macrophages and Paneth cells.
*More publications can be found for each product on its corresponding product page