Ensconsin Antibodies

AND MAP7 ELISA kits, Ensconsin Proteins

Many biological assays use antibodies to detect Ensconsin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ensconsin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ensconsin antibodies...

We validate the specificity of these antibodies to Ensconsin by testing them on tissues known to express MAP7 positively and negatively. Browse below to find the MAP7 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CCN4 Next: NFS1

MAP7 Infographic by Boster Bio

All MAP7 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-MAP7 Antibody

Human, Mouse, Rat

ELISA, IP, IF, IHC, ICC, WB

$370
Cat # A02131-1
100 μl/vial

MAP7 Overview

Facts about Ensconsin.

MAP7 3D structure. Source: alphafold

Ensconsin (MAP7)

Microtubule-stabilizing protein which may play a major role through reorganization of microtubules through polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic way.

May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and might link cytoskeletal microfilaments.

Gene Information

Human
Gene Name:	MAP7
Uniprot:	Q14244
Entrez:	9053

Family

Belongs to:

MAP7 family

Alternative Names

E-MAP-115dJ325F22.2 (microtubule-associated protein 7 (EMAP115, E-MAP-115)); ensconsin; Epithelial microtubule-associated protein of 115 kDa; MAP-7; microtubule-associated protein 7EMAP115

Molecular Weight

Mass (kDA):
84.052 kDA

Genomic Context


Human

Location:	6q23.3
Sequence:	6; NC_000006.12 (136342281..136550819, complement)

Tissue Specificity

Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas.

Subcellular Localizations

Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts.

Diseases

Malignant Neoplasms
Neoplasms
Carcinoma
Adenocarcinoma
5,10-methylenetetrahydrofolate Reductase Deficiency
Barrett's Adenocarcinoma
Barrett Esophagus
Esophageal Neoplasms
Tumor Progression
Colonic Neoplasms
Anemia, Sickle Cell
Familial Aplasia Of The Vermis

Malignant Tumor Of Colon
Myopathy
Colorectal Cancer
Congenital Structural Myopathy
Esophageal Adenocarcinoma
Cell Invasion
Congenital Abnormality

Pathways

Drug Resistance
Mrna Splicing
Cell Cycle
Locomotion
Localization
Spermatogenesis

PTMs

Phosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/MAP7

References

PMID: 8408219 by Masson D., et al. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells.

PMID: 7490279 by Masson D., et al. Binding of E-MAP-115 to microtubules is regulated by cell cycle- dependent phosphorylation.