Collagenase 3 (MMP13)

Plays a role in the degradation of extracellular matrix proteins such as fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen.

Can also degrade collagen type IV, type XIV and kind X. May also be the activating or degrading key regulatory proteins, such as TGFB1 and CTGF.