Protein LYRIC (Mtdh)

Downregulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF- kappa-B) transcription factor.

Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an impact on bone and brain metastasis, possibly by enhancing the seeding of tumor cells into the target organ endothelium.