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We validate the specificity of these antibodies to Mus81 by testing them on tissues known to express Mus81 positively and negatively. Browse below to find the Mus81 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Facts about Crossover junction endonuclease MUS81.
May be required in mitosis for the processing of stalled or collapsed replication forks. .
crossover junction endonuclease MUS81; EC 3.1.22; EC 3.1.22.-; FLJ21012; FLJ44872; MUS81 endonuclease homolog (S. cerevisiae); MUS81 endonuclease homolog (yeast); SLX3 structure-specific endonuclease subunit homolog; SLX3
Expressed highly in testis. Expressed also in bone marrow, brain, thymus and to a lesser extent in heart and skeletal muscle, colon, kidney and spleen.
You may be wondering if you should utilize high affinity primary antibodies or the Anti-MUS81 Marker. Both of these options depend on your research goals as well as the type of protein that you are trying to target. These sections offer suggestions and answers to questions about Boster Bio. Boster Bio also includes optimization guides and suggestions.
Antibody to MUS81 is available at Boster Bio. This antibody is a specific one for mice, humans and rats. It reacts with the protein p62. It is available from Boster Bio under the catalog number A00810.
Apart from his artistic talents, Steve Boster was a medical doctor for 33 years. In 2015, he turned his attention to painting full-time. He is currently employed at the Chicken Farm Art Center in San Angelo, Texas. His paintings feature animals and is still painted in vibrant colors. Boster has been an avid outdoorsman and hunter for most of his life. Boster has donated a percentage of his proceeds to the Fisher House Foundation which provides meals for veterans in the hospital.
A drug that targets Mus81 is a potent anti-cancer drug. BRD4 inhibitor AZD5153 blocks Mus81 expression and can also reduce cell migration. BRD4 hinders the growth of gastric cancer cells by changing Mus81 expression. However, many researchers question whether BRD4 inhibition will also reduce the rate of gastric cancer cells' migration.
These questions are only answered if we know what Mus81 is. Mus81 is multidomain protein that repairs cross-links in interstrands and bulky DNA lesions. BRD4 is thought to be a component of the BRD4 protein complex and regulates its expression. Boster Bio's anti-MUS81 antibody targets this gene. In addition, it also targets BRD4.
Mus81 has been the focus of numerous studies which have previously focused on its role in DNA structure and maintaining replication. However, recent studies have revealed that it has an important role in cancer cells, cell proliferation, apoptosis, and chemotherapy sensitivity. The current study demonstrated that Mus81 is crucial to the movement of cancerous gastric cells. Previous studies have proven that Mus81 is linked to ZEB1 which is an EMT inducer that is well-known.
Patients with high levels of Mus81 protein in their gastric cancer have a higher risk of lymph node metastasis. A positive anti-MUS81 antibody could be used to identify tumor cells whose expression has been affected by the disease. It can also determine if a tumor is able to expand from the stomach to other organs, including the lymph nodes. The results of the studies will assist doctors in deciding whether to treat their patients or wait to determine whether the treatment works.
The IgD gene is not present in mice, which leads to delayed affinity maturation of high-affinity prima antibodies, resulting in prolonged the development of autoimmune diabetes. IgD is necessary in the transition between primary autoreactive reactions and secondary antigen-specific antibody response responses. The absence of IgD can impact the production of these antibodies. The MUS81 marker was used to study the development of primary antibodies with high affinity.
High-affinity antibodies that use the Mus81 marker are bound to one specific epitope on the antigen of interest. Furthermore they are insensitive to washing, and have an extremely low amount of batch-to-bath variability. However this method is not suitable for applications that require sensitivity, for example, the detection of cancerous tumors in which the antibody can trigger allergic reactions. However, it does have several advantages over conventional monoclonal antibodies.
The MUS81 marker is a high-affinity protein. It is a prime example. It is capable of detecting specific epitopes. It can also identify multiple targets. Its affinity value can be measured using OI RD. In addition it can be used to evaluate antibodies for their effectiveness in vitro. Rabbit monoclonal antibodies made by Abcam, in contrast to mouse monoclonal antibodies, are distinguished by their higher affinity.
Immunohistochemistry tests require a high quality primary antibody that can recognize the epitope targeted for. To minimize background signals, the MUS81 marker is extremely specific. High-affinity primary antibody use the MUS81 marker to produce excellent results in immunostaining. However, a low-affinity antibody may not be as specific, so it is vital to conduct additional studies to confirm the results.
High-affinity primary antibodies using the Mus81 marker are particularly useful in studies where multiple epitopes are required to be identified. Single-specific IgGs have less cross-reactivity and lower affinity and require significant technical expertise and high-affinity primary antibodies utilize the MUS81 marker. The MUS81 marker increases the reproducibility of these antibodies by allowing the selection of the most optimal characteristics.
You might be wondering how to create an ELISA protocol that uses the MUS81 marker. Fortunately, Boster Bio offers a wide range of secondary antibodies, isotype control and detection systems designed for this specific marker. We will answer common questions in this article. Learn more about the basics of negative control conditions before starting your experiment.