Crossover junction endonuclease MUS81 (Mus81)

Interacts with EME1 and EME2 to form a DNA structure- specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates comprise 3'-flap structures, replication forks and nicked Holliday junctions.

May be required in mitosis for the processing of stalled or collapsed replication forks. .