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NCOA3 Antibodies
AND NCOA3 ELISA kits, NCOA3 Proteins
Many biological assays use antibodies to detect NCOA3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NCOA3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NCOA3 antibodies...
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NCOA3 Overview
Facts about Nuclear receptor coactivator 3.
Nuclear receptor coactivator 3 (NCOA3)
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Plays a central role in creating a multisubunit coactivator complex, which probably acts via remodeling of chromatin.
Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ER), retinoids (RARs and RXRs), thyroid gland (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Displays histone acetyltransferase activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | NCOA3 |
| Uniprot: | Q9Y6Q9 |
| Entrez: | 8202 |
Family
| Belongs to: |
|---|
| SRC/p160 nuclear receptor coactivator family |
Alternative Names
ACTR; ACTRCBP-interacting protein; AIB1; AIB1AIB-1; Amplified in breast cancer 1 protein; BHLHE42; bHLHe42p/CIP; CAGH16; Class E basic helix-loop-helix protein 42; CTG26; KAT13B; MGC141848; NCOA3; NCoA-3; nuclear receptor coactivator 3; pCIP ; pCIP; RAC3; RAC-3; RAC3pCIP; Receptor-associated coactivator 3; SRC-1; SRC3; SRC-3; SRC-3EC 2.3.1.48; Steroid receptor coactivator protein 3; Thyroid hormone receptor activator molecule 1; TNRC16; TRAM1; TRAM-1TNRC14
Molecular Weight
Mass (kDA):
155.293 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q13.12 |
| Sequence: | 20; NC_000020.11 (47501887..47656872) |
Tissue Specificity
Widely expressed. High expression in heart, skeletal muscle, pancreas and placenta. Low expression in brain, and very low in lung, liver and kidney.
Subcellular Localizations
Cytoplasm. Nucleus. Mainly cytoplasmic and weakly nuclear. Upon TNF activation and subsequent phosphorylation, it translocates from the cytoplasm to the nucleus.
Diseases
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Neoplasms
- Mammary Neoplasms
- Carcinoma
- Cell Transformation, Neoplastic
- Neoplasm Metastasis
- Malignant Neoplasm Of Prostate
- Prostatic Neoplasms
- Hyperplasia
- Adenocarcinoma
- Malignant Paraganglionic Neoplasm
Interacting Proteins
- ATAD2
- CARM1
- EP300
- ESR1
- IKBKB
- PSMB9
- PSME3
- PTEN
- RARA
- SPOP
Pathways
- Cell Proliferation
- Cell Growth
- Cell Cycle
- Localization
- Histone Acetylation
- Pathogenesis
- Chromatin Remodeling
- Translation
- Oncogenesis
- Rna Interference
- Cell Migration
- Nuclear Export
- Energy Homeostasis
PTMs
- Phosphorylation
- Acetylation
- Methylation
Research Areas
- Cancer
- Chromatin Research
- Transcription Factors and Regulators
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NCOA3
bosterbio.com/bosterbio-gene-info-cards/NCOA3
References
PMID: 9346901 by Takeshita A., et al. TRAM-1, a novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.
PMID: 9267036 by Chen H., et al. Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.