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- Table of Contents
CHAF1B Antibodies
AND CHAF1B ELISA kits, CHAF1B Proteins
Many biological assays use antibodies to detect CHAF1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CHAF1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CHAF1B antibodies...
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CHAF1B Infographic by Boster Bio
All CHAF1B Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
IF, IHC, WB
$523
Cat # M03959
100 µl
Cat # M03959
100 µl
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M03959-1
100 μl/vial
Cat # M03959-1
100 μl/vial
CHAF1B Overview
Facts about Chromatin assembly factor 1 subunit B.
Chromatin assembly factor 1 subunit B (CHAF1B)
Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro.
CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to finish the histone octamer. .
Gene Information
| Human | |
|---|---|
| Gene Name: | CHAF1B |
| Uniprot: | Q13112 |
| Entrez: | 8208 |
Family
| Belongs to: |
|---|
| WD repeat HIR1 family |
Alternative Names
CAF1; CAF-1; CAF1ACAF-1 subunit B; CAF1P60CAF-I 60 kDa subunit; CAF-IP60; chromatin assembly factor 1 subunit B; chromatin assembly factor 1, subunit B (p60); Chromatin assembly factor I p60 subunit; human chromatin assembly factor-I p60 subunit, 10; MPHOSPH7CAF-I p60; MPP7M-phase phosphoprotein 7
Molecular Weight
Mass (kDA):
61.493 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 21q22.12-q22.13 |
| Sequence: | 21; NC_000021.9 (36380145..36419015) |
Subcellular Localizations
Nucleus. Cytoplasm. DNA replication foci. Cytoplasmic in M phase.
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Paraganglionic Neoplasm
- Down Syndrome
- Carcinoma
- Genomic Instability
- Trisomy
- Salivary Gland Neoplasms
- Sclerosis
- Neoplasm Metastasis
- Malignant Neoplasm Of Breast
- Glioma
Interacting Proteins
- ASF1A
- ASF1B
Pathways
- Chromatin Assembly
- Dna Replication
- Nucleosome Assembly
- Cell Cycle
- Dna Repair
- S Phase
- Cell Division
- Localization
- Gene Silencing
- Chromatin Organization
- Cell Proliferation
- Interphase
- Mitosis
PTMs
- Phosphorylation
- Acetylation
- Methylation
Research Areas
- Apoptosis
- Cancer
- Cell Cycle and Replication
- Chromatin Research
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CHAF1B
bosterbio.com/bosterbio-gene-info-cards/CHAF1B
References
PMID: 7600578 by Kaufman P.D., et al. The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication.
PMID: 8885239 by Matsumoto-Taniura N., et al. Identification of novel M phase phosphoproteins by expression cloning.