Nek8 Antibodies

AND Nek8 ELISA kits, Nek8 Proteins

Many biological assays use antibodies to detect Nek8, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nek8 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nek8 antibodies...

We validate the specificity of these antibodies to Nek8 by testing them on tissues known to express Nek8 positively and negatively. Browse below to find the Nek8 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Nek8 Infographic by Boster Bio

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NEK8 (NM_178170) Human Over-expression Lysate

Human

$960
Cat # LS284086
20 µg, 100 µg

Nek8 Overview

Facts about Serine/threonine-protein kinase Nek8.

Serine/threonine-protein kinase Nek8 (Nek8)

Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells.

May regulate ciliary biogenesis through targeting of proteins into the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.

Gene Information

Mouse
Gene Name:	Nek8
Uniprot:	Q91ZR4
Entrez:	140859

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; EC 2.7.11.1; JCKNIMA-related kinase 12a; MGC138445; NEK12A; nephrocystin 9; Never in mitosis A-related kinase 8; NIMA (never in mitosis gene a)- related kinase 8; Nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9NIMA-family kinase NEK8; serine/threonine-protein kinase Nek8; serine/thrionine-protein kinase NEK8

Molecular Weight

Mass (kDA):
75.265 kDA

Genomic Context


Mouse

Location:	11 B5\|11 46.74 cM
Sequence:	11;

Tissue Specificity

Kidney, liver, and testis.

Diseases

Kidney Diseases
Cystic Kidney Diseases
Polycystic Kidney Diseases
Nephronophthisis
Cystic Disease -retired-
Malignant Neoplasms
Kidney Failure, Chronic
Polycystic Kidney, Autosomal Dominant
Autosomal Recessive Polycystic Kidney Disease
Tissue Adhesions
Kidney Failure
Reperfusion Injury
Hydrocephalus, Normal Pressure

Cardiovascular Abnormalities
Spinal Cord Injuries
Malignant Neoplasm Of Breast
Familial Aplasia Of The Vermis
Injury To Kidney
Neoplasms
Cat Diseases

Pathways

Localization
Mitosis
Cell Cycle
Pathogenesis
Cell Proliferation
Chromosome Condensation
Transport
Cell Adhesion
Centromere Separation
Protein Transport
Cytokinesis
Regeneration
Cell Division

Pronephros Morphogenesis
Bone Remodeling
Heart Looping
Spindle Assembly Checkpoint
Interphase
Spindle Assembly
Secretion

PTMs

Phosphorylation

Research Areas

Protein Kinase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Nek8

References

PMID: 12421721 by Liu S., et al. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish.

PMID: 16267153 by Mahjoub M.R., et al. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes.