Non-homologous end-joining factor 1 (Nhej1)

DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and another NHEJ factors located at DNA ends, or may participate in reconfiguration of the conclusion bound NHEJ factors to permit XRCC4 access to the DNA termini.

It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several kinds of mismatched ends that are noncomplementary or partially complementary (PubMed:17360556). Binds DNA in a length-dependent way (By similarity).