NR1I2 Antibodies

AND NR1I2 ELISA kits, NR1I2 Proteins

Many biological assays use antibodies to detect NR1I2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR1I2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR1I2 antibodies...

We validate the specificity of these antibodies to NR1I2 by testing them on tissues known to express NR1I2 positively and negatively. Browse below to find the NR1I2 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NR1I2 Infographic by Boster Bio

All NR1I2 Products

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Anti-PXR/NR1I2 Antibody Picoband®

2 Citations 1 Q&As

Western blot analysis of NR1I2 using anti-NR1I2 antibody (A01133-3)

IHC analysis of NR1I2 using anti-NR1I2 antibody (A01133-3)

Human, Mouse, Rat

ELISA, Flow Cytometry, IHC, WB

$370
Cat # A01133-3
100 μg/vial

PXR (NR1I2) (NM_003889) Human Over-expression Lysate

Human

$628
Cat # LS008856
20 µg, 100 µg

NR1I2 Overview

Facts about Nuclear receptor subfamily 1 group I member 2.

NR1I2 3D structure. Source: alphafold

Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Nuclear receptor that binds and is activated by number of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of possibly harmful xenobiotics, drugs and endogenous compounds.

Activated from the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific.

Gene Information

Human
Gene Name:	NR1I2
Uniprot:	O75469
Entrez:	8856

Family

Belongs to:

nuclear hormone receptor family

Alternative Names

BXR; NR1I2; nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group I, member 2; ONR1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR; PAR1; PAR2; Pregnane X receptor; PRR; PXR; PXRPARq; SAR; Steroid and xenobiotic receptor; SXR; SXRBXR

Molecular Weight

Mass (kDA):
49.762 kDA

Genomic Context


Human

Location:	3q13.33
Sequence:	3; NC_000003.12 (119780484..119818485)

Tissue Specificity

Expressed in liver, colon and small intestine.

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Inflammatory Bowel Diseases
Carcinoma
Intestinal Diseases
Cholestasis
Inflammation
Neoplasms
Cholangiocarcinoma
Dysequilibrium Syndrome
Liver Carcinoma
Liver Diseases
Intrahepatic Cholestasis
Crohn Disease

Ulcerative Colitis
Hiv Infections
Kidney Neoplasm
Ulcer
Adenocarcinoma
Colorectal Cancer
Renal Cell Carcinoma

Interacting Proteins

HSP90AB1
NCOA1

Pathways

Transport
Drug Transport
Inflammatory Response
Localization
Drug Resistance
Excretion
Immune Response
Gluconeogenesis
Glucose Homeostasis
Reverse Transcription
Translation
Cell Cycle
Lipid Homeostasis

Oxygen Transport
Receptor Transactivation
Circadian Rhythm
Dna Methylation
Methylation
Cell Death
Biological Regulation

PTMs

Phosphorylation
Methylation

Demethylation
Hydroxylation

Research Areas

Stem Cell Markers
Transcription Factors and Regulators

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR1I2

References

PMID: 9784494 by Blumberg B., et al. SXR, a novel steroid and xenobiotic-sensing nuclear receptor.

PMID: 9727070 by Lehmann J.M., et al. The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.