Serine/threonine-protein kinase PAK 2 (PAK2)

Serine/threonine protein kinase that plays a role in many different different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Activation from the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.

Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.