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- Table of Contents
PAK2 Antibodies
AND PAK2 ELISA kits, PAK2 Proteins
Many biological assays use antibodies to detect PAK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PAK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PAK2 antibodies...
Designing a Western blot for PAK2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PAK2 Western Blot GuideDesigning an IHC experiment for PAK2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PAK2 IHC GuidePAK2 Infographic by Boster Bio
All PAK2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01419-4
100 μg/vial
Cat # A01419-4
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2576
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2576
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2575
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2575
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2170
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2170
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1437
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1437
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2103
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2103
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01419
100 μl
Cat # M01419
100 μl
PAK2 Overview
Facts about Serine/threonine-protein kinase PAK 2.
Serine/threonine-protein kinase PAK 2 (PAK2)
Serine/threonine protein kinase that plays a role in many different different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Activation from the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues.
Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.
Gene Information
| Human | |
|---|---|
| Gene Name: | PAK2 |
| Uniprot: | Q13177 |
| Entrez: | 5062 |
Family
| Belongs to: |
|---|
| protein kinase superfamily |
Alternative Names
EC 2.7.11; gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; PAK2; PAK-2; PAK65; PAK65EC 2.7.11.1; PAKgamma; S6/H4 Kinase; serine/threonine-protein kinase PAK 2
Molecular Weight
Mass (kDA):
58.043 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3q29 |
| Sequence: | 3; NC_000003.12 (196739857..196832647) |
Tissue Specificity
Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
Subcellular Localizations
[Serine/threonine-protein kinase PAK 2]: Cytoplasm. MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.; [PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
Diseases
- Hiv Infections
- Neoplasms
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
- Tissue Adhesions
- Carcinoma
- Acquired Immunodeficiency Syndrome
- Malignant Paraganglionic Neoplasm
- Cell Invasion
- Malignant Neoplasm Of Breast
- Cell Transformation, Neoplastic
- Leukemia
Interacting Proteins
- ARHGEF6
- ARHGEF7
- Arhgef7
- CASP7
- CDC42
- GRB2
- HCK
- HTT
- LIMK1
- NCK1
Pathways
- Cell Death
- Localization
- Pathogenesis
- Cell Cycle
- Cell Migration
- Cell Proliferation
- Cell Adhesion
- Cell Motility
- Chemotaxis
- Cell Growth
- Proteolysis
- Viral Replication
- T Cell Activation
PTMs
- Phosphorylation
- Cleavage
- Myristoylation
Research Areas
- Protein Kinase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAK2
bosterbio.com/bosterbio-gene-info-cards/PAK2
References
PMID: 7744004 by Martin G.A., et al. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.
PMID: 7673144 by Benner G.E., et al. Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation.