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- Table of Contents
Facts about Serine/threonine-protein kinase PAK 2.
Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration.
Human | |
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Gene Name: | PAK2 |
Uniprot: | Q13177 |
Entrez: | 5062 |
Belongs to: |
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protein kinase superfamily |
EC 2.7.11; gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; PAK2; PAK-2; PAK65; PAK65EC 2.7.11.1; PAKgamma; S6/H4 Kinase; serine/threonine-protein kinase PAK 2
Mass (kDA):
58.043 kDA
Human | |
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Location: | 3q29 |
Sequence: | 3; NC_000003.12 (196739857..196832647) |
Ubiquitously expressed. Higher levels seen in skeletal muscle, ovary, thymus and spleen.
[Serine/threonine-protein kinase PAK 2]: Cytoplasm. MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane.; [PAK-2p34]: Nucleus. Cytoplasm, perinuclear region. Membrane; Lipid-anchor. Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane.
If you're interested in PAK2 research, you've probably been wondering about Boster's offerings. In this article, we'll go over the background of the company, its most significant products, and ongoing projects. We've got some advice to help you make your decision. Before you buy, make sure that you read the description.
High-affinity primary antibodies are available for flow cytometry. This technology lets researchers identify proteins of interest from the cells or particles. The antibody can be polyclonal or monoclonal and is widely recognized for its high specificity. Boster offers a wide range of products for flow-cytometry. Below are a few of the most sought-after ones.
Primary antibodies are immunoglobulins obtained from host animals. They also contain complementing determinants. Complementarity determinants are complex topics, but here's a look at the most significant components. Primary antibodies are generated by immunizing an animal host with antigens, and then removing the proteins from its eggs or serum. Once primary antibodies are made, they can be used to detect the antigens, measure them and purify them of interest.
Secondary antibody conjugates are highly efficient in multiple applications. They can be used to double-labeled specimens. This allows researchers to ask more questions from the same specimen and obtain more context information. Additionally, it allows researchers to determine the presence or absence of a specific cell or protein in a sample. Thus, they can determine whether an organ is developing cancer or not.
Boster's story is the result of a study that is scholarly about disability in the slave institution. The book uncovers a complex network of institutions and people who shaped how people with disabilities were treated at the institution. It uses both traditional texts and challenging sources. They also helped Boster to market, market, and sell his products. Boster's story is as fascinating as its subject because of the compelling voice of the author.
Boster has been a leader in the area of antibodies for more than 25 years. Their high-affinity primary antibody is cited extensively in the scientific literature. Their antibodies are validated for use in Western blotting, immunohistochemistry, and ELISA. Their products are suitable for all researchers and can help accelerate research in many different areas. The PAK2 marker that regulates apoptosis activity is a crucial component of the immune system.
The presence of a functional motif, which interacts with Nef proteins, is essential for molecular biology of PAK2 genes. We have found three Nef proteins that interact with PAK2 when it is expressed via mRNA. This interaction could have implications for the function of PAK2 in the cell. Current research using the PAK2 marker include the examination of the role played by this particular motif in regulating cell growth and differentiation.
The full-length active PAK2 is extremely resistant to caspase-mediated cleavage, indicating constitutive activation of the gene. We have confirmed this through various biochemical experiments and in the vivo cell tests. Cell death is caused by serum or hydrogen peroxide starvation. PAK2 activation is required. This property is relevant to the response of cells to both of these conditions.
A chimera of the PAK2 gene and the human ER identifies the presence of both PAK1 and PAK2. The two markers have similarity in their ability to induce cell death in response to signals ER-dependent. However, since their molecular weights differ, these chimeras might have different anti-apoptotic functions. In some cases, the mutations can cause cells to die through cardiac arrest.
These mutations decrease autophosphorylation and increase PAK1 kinase activity. The S490A and S490D mutants are immune to caspase 3-mediated activation. The mutations at Ser490 a residue near the C-terminus, increase PAK1 activity by decreasing dimerization. It is also known that Ser490 is involved in directing PAK2 towards the endoplasmic retinal and plasma membrane.
PMID: 7744004 by Martin G.A., et al. A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20.
PMID: 7673144 by Benner G.E., et al. Activation of an S6/H4 kinase (PAK 65) from human placenta by intramolecular and intermolecular autophosphorylation.