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- Table of Contents
PARP2 Antibodies
AND PARP2 ELISA kits, PARP2 Proteins
Many biological assays use antibodies to detect PARP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARP2 antibodies...
Designing a Western blot for PARP2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PARP2 Western Blot GuidePARP2 Infographic by Boster Bio
All PARP2 Products
Product
Figures
Specificity
Applications
Price
Human, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A03270-2
100 μg/vial
Cat # A03270-2
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M03270-1
100 μl/vial
Cat # M03270-1
100 μl/vial
PARP2 Overview
Facts about Poly [ADP-ribose] polymerase 2.
Poly [ADP-ribose] polymerase 2 (PARP2)
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin structure and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231).
Mediates serine ADP-ribosylation of target proteins after interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). .
Gene Information
| Human | |
|---|---|
| Gene Name: | PARP2 |
| Uniprot: | Q9UGN5 |
| Entrez: | 10038 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2; ADPRT-2; ADPRT2pADPRT-2; ADPRTL2EC 2.4.2.30; ADPRTL3; hPARP-2; NAD(+) ADP-ribosyltransferase 2; PARP-2; poly (ADP-ribose) polymerase 2; poly (ADP-ribose) polymerase family, member 2; poly (ADP-ribosyl) transferase-like 2; poly [ADP-ribose] polymerase 2; poly(ADP-ribose) synthetase; Poly[ADP-ribose] synthase 2; poly[ADP-ribose] synthetase 2
Molecular Weight
Mass (kDA):
66.206 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q11.2 |
| Sequence: | 14; NC_000014.9 (20343041..20357904) |
Tissue Specificity
Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.
Subcellular Localizations
Nucleus.
Diseases
- Neoplasms
- Malignant Neoplasms
- Genomic Instability
- Malignant Neoplasm Of Breast
- Malignant Paraganglionic Neoplasm
- Fanconi Anemia
- Neoplasm Metastasis
- Melanoma
- Neurodegenerative Disorders
- Ataxia
- Neoplasms, Experimental
- Glioma
- Stromal Neoplasm
Interacting Proteins
- FKBP3
- STAC
Pathways
- Cell Death
- Dna Repair
- Cell Cycle
- Chromatin Remodeling
- Dna Replication
- Pathogenesis
- Rna Interference
- Cell Cycle Checkpoint
- Gene Silencing
- Fertilization
- Double-strand Break Repair
- Cell Proliferation
- Localization
PTMs
- Ribosylation
Research Areas
- Apoptosis
- DNA Repair
- Hypoxia
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARP2
bosterbio.com/bosterbio-gene-info-cards/PARP2
References
PMID: 10364231 by Ame J.-C., et al. PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.
PMID: 10329013 by Johansson M.; A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues.