Poly [ADP-ribose] polymerase 2 (PARP2)

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin structure and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231).

Mediates serine ADP-ribosylation of target proteins after interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). .