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- Table of Contents
Facts about Alpha-parvin.
Plays a role in sprouting angiogenesis and is needed for normal adhesion of vascular smooth muscle cells into endothelial cells during blood vessel growth (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis.
Human | |
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Gene Name: | PARVA |
Uniprot: | Q9NVD7 |
Entrez: | 55742 |
Belongs to: |
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parvin family |
Actopaxin; alphaParvin; alpha-Parvin; Calponin-like integrin-linked kinase-binding protein; CH-ILKBP; FLJ10793; FLJ12254; FLJ25106; FLJ46049; Matrix-remodeling-associated protein 2; matrix-remodelling associated 2; MXRA2; PARVA; parvin, alpha
Mass (kDA):
42.244 kDA
Human | |
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Location: | 11p15.3 |
Sequence: | 11; NC_000011.10 (12376441..12535356) |
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Constituent of focal adhesions. Associates with the actin cytoskeleton.
PARVA, also known as the parvalbumin, a protein that is new and used to detect DNA and RNA. This protein is highly immunegenic, which means that it can be used as a tool to detect a wide range of biological processes. PARVA, a protein found in our bodies, is also known as PARVA. PARVA is well-known for its biochemical properties and as an antioxidant. This property allows researchers to detect and prevent oxidative stress.
American anthropologist Steven Boster invented the PARVA mark. This marker is used to study human evolution and human behaviour. His research has been published in many scientific journals, including Science and Human Values and the Annual Meeting of the Anthropological Society of America. Below, he explains how the PARVA marker works and the advantages it offers.
A monoclonal antibody recognizing a specific antigen and binding to it with high affinity is known as a high-affinity prima antibody. This type of antibody can be used in research as well as for purification of antigens. High-affinity primaries are created in animals as hosts. Here are some of the benefits of high-affinity primary antibodies. Learn how to use these antibodies.
This antibody binds specifically to the target antigen and reduces background staining. This is important since background staining can be quite high in conventional immunohistochemistry methods. The monoclonal antibody can be made in a wide variety of concentrations, which allows multiplexing. It also reduces chemical waste and allows precise staining complex tissues and samples.
High-affinity primary antibodies can recognize antigens of particular interest, such proteins found in living cells. They are also capable of recognizing post-translational changes. They can also recognize proteins that could cause disease. These antibodies have undergone extensive validation in a variety of research applications. Many have also undergone protein array or knockout validation. Research has begun to show the utility of these antibodies.
IHC/ICC experiments will require a high-affinity primary antibody. Because antibodies need to be specific to an epitope, all steps of the experiment must be optimized to minimize background signals. This includes initial studies that determine the right working dilutions to use for monoclonal or polyclonal antibody. Since polyclonal antibodies exhibit minimal cross-reactivity, working dilutions are important in this process.
This technique also includes improved reagents, methods for amplification and detection of antigens. A bispecific antibody is capable of distinguishing between an antigen of a therapeutic or non-therapeutic nature. The bispecific antigen can also be used for diagnosing, localizing and treating a particular lesion. You can use this antibody for many purposes, including to detect cancer states, viral infections, parasites, among others.
PMID: 11171322 by Olski T.M., et al. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily.
PMID: 11331308 by Tu Y., et al. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading.