Alpha-parvin (PARVA)

Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract.

Plays a role in sprouting angiogenesis and is needed for normal adhesion of vascular smooth muscle cells into endothelial cells during blood vessel growth (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis.