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- Table of Contents
Alpha-parvin Antibodies
AND PARVA ELISA kits, Alpha-parvin Proteins
Many biological assays use antibodies to detect Alpha-parvin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alpha-parvin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alpha-parvin antibodies...
Designing an IHC experiment for Alpha-parvin? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PARVA IHC GuidePARVA Infographic by Boster Bio
All PARVA Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IP, IHC, WB
$370
Cat # M04041
100 μl
Cat # M04041
100 μl
Zebrafish
WB
$470
Cat # AZQ6DRM4
100 μg/vial
Cat # AZQ6DRM4
100 μg/vial
Human, Mouse
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M04056-1
100 μl/vial
Cat # M04056-1
100 μl/vial
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M04041-3
20μL, 40μL, 100μL, 200μL
Cat # M04041-3
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
WB
$370
Cat # M04049
100 μl/vial
Cat # M04049
100 μl/vial
PARVA Overview
Facts about Alpha-parvin.
Alpha-parvin (PARVA)
Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract.
Plays a role in sprouting angiogenesis and is needed for normal adhesion of vascular smooth muscle cells into endothelial cells during blood vessel growth (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis.
Gene Information
| Human | |
|---|---|
| Gene Name: | PARVA |
| Uniprot: | Q9NVD7 |
| Entrez: | 55742 |
Family
| Belongs to: |
|---|
| parvin family |
Alternative Names
Actopaxin; alphaParvin; alpha-Parvin; Calponin-like integrin-linked kinase-binding protein; CH-ILKBP; FLJ10793; FLJ12254; FLJ25106; FLJ46049; Matrix-remodeling-associated protein 2; matrix-remodelling associated 2; MXRA2; PARVA; parvin, alpha
Molecular Weight
Mass (kDA):
42.244 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11p15.3 |
| Sequence: | 11; NC_000011.10 (12376441..12535356) |
Tissue Specificity
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
Subcellular Localizations
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Constituent of focal adhesions. Associates with the actin cytoskeleton.
Diseases
- Theileriasis
- Infection By Theileria Parva
- Infective Disorder
- Cattle Diseases
- Salivary Gland Diseases
- Tick-borne Diseases
- Tissue Adhesions
- Babesiosis
- Sheep Diseases
- Parasitic Diseases
- Coccidiosis
- Lymphoproliferative Disorders
Interacting Proteins
- ILK
- Ilk
- MOCOS
Pathways
- Immune Response
- Pathogenesis
- Cell Adhesion
- Localization
- Cell Proliferation
- Cell Growth
- Lymphocyte Proliferation
- Cell Migration
- Transport
- Cell Cycle
- Secretion
- Virulence
- Cell Death
PTMs
- Phosphorylation
- Cleavage
- Nitration
- Reduction
- Glycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARVA
bosterbio.com/bosterbio-gene-info-cards/PARVA
References
PMID: 11171322 by Olski T.M., et al. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily.
PMID: 11331308 by Tu Y., et al. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading.