E3 ubiquitin-protein ligase CHFR (CHFR)

E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively slowing passing into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus.

Probably involved in signaling the presence of mitotic stress brought on by microtubule poisons by mediating the'Lys-48'-linked ubiquitination of target proteins, resulting in their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1.