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- Table of Contents
PDK1 Antibodies
AND PDK1 ELISA kits, PDK1 Proteins
Many biological assays use antibodies to detect PDK1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDK1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDK1 antibodies...
Designing a Western blot for PDK1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PDK1 Western Blot GuidePDK1 Infographic by Boster Bio
All PDK1 Products
Product
Figures
Specificity
Applications
Price
Anti-Glutaminase/GLS Antibody Picoband®
4 Citations
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01272-2
100 μg/vial
Cat # A01272-2
100 μg/vial
Human, Rat
ELISA, IHC, WB
$370
Cat # A01268-1
100 μg/vial
Cat # A01268-1
100 μg/vial
Human, Rat
IHC, WB
$370
Cat # PA1993
100 μg/vial
Cat # PA1993
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A01268-3
100 µg/vial
Cat # A01268-3
100 µg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2493
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2493
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$480
Cat # EKC1449
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1449
1 kit, containing one 96-well plate and all necessary reagents
PDK1 Overview
Facts about [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial.
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1)
Kinase that plays an integral role in regulation of glucose and fatty acid metabolism and homeostasis through phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate.
Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Gene Information
| Human | |
|---|---|
| Gene Name: | PDK1 |
| Uniprot: | Q15118 |
| Entrez: | 5163 |
Family
| Belongs to: |
|---|
| PDK/BCKDK protein kinase family |
Alternative Names
EC 2.7.11; EC 2.7.11.2; mitochondrial pyruvate dehydrogenase, lipoamide, kinase isoenzyme 1; PDH kinase 1; PDK1; PDK-1; PKB kinase; Pyruvate dehydrogenase kinase isoform 1; pyruvate dehydrogenase kinase, isoenzyme 1; pyruvate dehydrogenase kinase, isozyme 1; Pyruvate dehydrogenase lipoamide kinase isozyme 1, mitochondrial
Molecular Weight
Mass (kDA):
49.244 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q31.1 |
| Sequence: | 2; NC_000002.12 (172555373..172672698) |
Tissue Specificity
Expressed predominantly in the heart. Detected at lower levels in liver, skeletal muscle and pancreas.
Subcellular Localizations
Mitochondrion matrix.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Diabetes Mellitus
- Carcinoma
- Malignant Neoplasm Of Breast
- Hypoxia
- Mammary Neoplasms
- Insulin Resistance
- Inflammation
- Tissue Adhesions
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Prostate
Interacting Proteins
- PDHA1
- PKN2
Pathways
- Cell Growth
- Cell Proliferation
- Localization
- Cell Cycle
- Cell Death
- Transport
- Translation
- Secretion
- Pathogenesis
- Rna Interference
- Cell Migration
- Angiogenesis
- Glycolysis
PTMs
- Phosphorylation
- Dephosphorylation
- Oxidation
- Cleavage
- Myristoylation
- Methylation
- Ubiquitination
- Reduction
Research Areas
- Cancer
- Cell Biology
- Cellular Markers
- Hypoxia
- Lipid and Metabolism
- Protein Kinase
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDK1
bosterbio.com/bosterbio-gene-info-cards/PDK1
References
PMID: 7499431 by Gudi R., et al. Diversity of the pyruvate dehydrogenase kinase gene family in humans.
PMID: 18541534 by McFate T., et al. Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.
2 Publications of Boster PDK1 Antibodies & ELISA Kits
- PubMed ID: 29845188, lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPAR? p...
- PubMed ID: 19816521, Xu K, Ding Q, Fang Z, Zheng J, Gao P, Lu Y, Zhang Y. Cancer Gene Ther. 2010 Mar;...
*More publications can be found for each product on its corresponding product page