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PLOD1 Antibodies
AND PLOD1 ELISA kits, PLOD1 Proteins
Many biological assays use antibodies to detect PLOD1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLOD1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLOD1 antibodies...
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PLOD1 Infographic by Boster Bio
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PLOD1 Overview
Facts about Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1.
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1)
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is needed for normal assembly and cross-linkling of collagen fibrils (By similarity). Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens (PubMed:8621606, PubMed:10686424, PubMed:15854030).
These hydroxylysines serve as sites of attachment for carbohydrate components and are vital for the stability of the intermolecular collagen cross-links (Probable). .
Gene Information
| Human | |
|---|---|
| Gene Name: | PLOD1 |
| Uniprot: | Q02809 |
| Entrez: | 5351 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
2-oxoglutarate 5-dioxygenase 1; EC 1.14.11.4; Ehlers-Danlos syndrome type VI); FLJ42041; LH1; LLH; lysine hydroxylase; Lysyl hydroxylase 1; PLODLH; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase (lysine hydroxylase; procollagen-lysine 1, 2-oxoglutarate 5-dioxygenase 1; procollagen-lysine; procollagen-lysine, 2-oxoglutarate 5-dioxygenase
Molecular Weight
Mass (kDA):
83.55 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p36.22 |
| Sequence: | 1; NC_000001.11 (11934717..11975537) |
Subcellular Localizations
Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side.
Diseases
- Ehlers-danlos Syndrome
- Connective Tissue Diseases
- Muscle Hypotonia
- Kyphoscoliosis Deformity Of Spine
- Acquired Kyphosis
- Joint Laxity
- Osteoporosis
- Osteopenia
- Neoplasms
- Scoliosis, Unspecified
- Dysequilibrium Syndrome
- Ehlers-danlos Syndrome, Hydroxylysine-deficient
- Corneal Diseases
Interacting Proteins
- HNRNPH2
Pathways
- Cell Cycle
- Transport
- Osteoblast Differentiation
- Aging
- Regulation Of Gene Expression
- Histone Modification
- Metaphase
- Oocyte Maturation
- Biosynthetic Process
- Rna Splicing
- Flight
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLOD1
bosterbio.com/bosterbio-gene-info-cards/PLOD1
References
PMID: 1577494 by Hautala T., et al. Cloning of human lysyl hydroxylase: complete cDNA-derived amino acid sequence and assignment of the gene (PLOD) to chromosome 1p36.3- p36.2.
PMID: 7713497 by Heikkinen J., et al. Structure and expression of the human lysyl hydroxylase gene (PLOD): introns 9 and 16 contain Alu sequences at the sites of recombination in Ehlers-Danlos syndrome type VI patients.