- Table of Content
POLQ functions as an inhibitor of homology-recombination repair (HR) pathway by restricting RAD51 accumulation at resected ends (PubMed:25642963). POLQ-mediated MMEJ may be required to foster the survival of cells with a compromised HR repair pathway, thereby preventing genomic havoc by resolving unrepaired lesions (By similarity).
|DNA polymerase type-A family|
|Sequence:||3; NC_000003.12 (121431431..121545988, complement)|
Highly expressed in testis.
Nucleus. Chromosome. Enriched in chromatin in response to ultaviolet (UV) light (PubMed:25642963). Binds to chromatin during early G1 (PubMed:24989122).