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PPP1R12A Antibodies
AND PPP1R12A ELISA kits, PPP1R12A Proteins
Many biological assays use antibodies to detect PPP1R12A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP1R12A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP1R12A antibodies...
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PPP1R12A Infographic by Boster Bio
All PPP1R12A Products
Product
Figures
Specificity
Applications
Price
Anti-Myosin Phosphatase/PPP1R12A Antibody Picoband®
3 Citations 1 Q&As
Human, Monkey, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9737
100 μg/vial
Cat # PB9737
100 μg/vial
Human, Monkey, Mouse, Rat
IF, ICC, WB
$370
Cat # PA1681
100 μg/vial
Cat # PA1681
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01743T853-1
100ul
Cat # A01743T853-1
100ul
Human, Mouse, Rat
ELISA, IF, IHC, WB
$380
Cat # A01743T696-1
100ul
Cat # A01743T696-1
100ul
Human
$960
Cat # LS004659
20 µg, 100 µg
Cat # LS004659
20 µg, 100 µg
Human
ELISA, IP, IF, IHC, WB
$146
Cat # M01743-1
20μL, 40μL, 100μL, 200μL
Cat # M01743-1
20μL, 40μL, 100μL, 200μL
Human, Mouse, Rat
WB
$370
Cat # M01743
100 μl/vial
Cat # M01743
100 μl/vial
PPP1R12A Overview
Facts about Protein phosphatase 1 regulatory subunit 12A.
Protein phosphatase 1 regulatory subunit 12A (PPP1R12A)
Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin.
As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN- dependent suppression of HIF1A activity.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPP1R12A |
| Uniprot: | O14974 |
| Entrez: | 4659 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
MBSmyosin phosphatase, target subunit 1; MGC133042; Myosin phosphatase target subunit 1; Myosin phosphatase-targeting subunit 1; MYPT1protein phosphatase 1 regulatory subunit 12A; protein phosphatase 1, regulatory (inhibitor) subunit 12A; Protein phosphatase myosin-binding subunit
Molecular Weight
Mass (kDA):
115.281 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q21.2-q21.31 |
| Sequence: | 12; NC_000012.12 (79773563..79935455, complement) |
Tissue Specificity
Expressed in striated muscles, specifically in type 2a fibers (at protein level).
Subcellular Localizations
Cytoplasm. Cytoplasm, cytoskeleton, stress fiber. Also along actomyosin filaments.
Diseases
- Pathologic Vasoconstriction
- Hypertensive Disease
- Tissue Adhesions
- Diabetes Mellitus
- Hypoxia
- Malignant Neoplasms
- Neoplasms
- Insulin Resistance
- Hyperplastic Polyp
- Observation Of Neuromuscular Block
- Diabetes Mellitus, Non-insulin-dependent
- Pulmonary Hypertension
- Aggressive Systemic Mastocytosis
Interacting Proteins
- DAPK3
- FOS
Pathways
- Sensitization
- Muscle Contraction
- Smooth Muscle Contraction
- Vasoconstriction
- Localization
- Cell Migration
- Cell Growth
- Vascular Smooth Muscle Contraction
- Cell Cycle
- Cell Proliferation
- Vasodilation
- Mitosis
- Rna Interference
PTMs
- Phosphorylation
- Dephosphorylation
- Demethylation
- Nitrosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP1R12A
bosterbio.com/bosterbio-gene-info-cards/PPP1R12A
References
PMID: 9286714 by Takahashi N., et al. Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21.
PMID: 11342221 by Machida H., et al. Molecular cloning and analysis of the 5'-flanking region of human MYPT1 gene.
2 Publications of Boster PPP1R12A Antibodies & ELISA Kits
- PubMed ID: 10.4103/1673-5374.165512, The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in...
- PubMed ID: 26604905, The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in...
*More publications can be found for each product on its corresponding product page