PR domain zinc finger protein 1 (PRDM1)

Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types like tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, like the gut and skin, but also in other nonbarrier tissues such as liver and liver, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity).

Binds specifically to the PRDI element in the promoter of this beta-interferon gene (PubMed:1851123). Drives the maturation of B- lymphocytes into Ig secreting cells (PubMed:12626569).