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- Table of Contents
Facts about PR domain zinc finger protein 1.
Binds specifically to the PRDI element in the promoter of this beta-interferon gene (PubMed:1851123). Drives the maturation of B- lymphocytes into Ig secreting cells (PubMed:12626569).
Human | |
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Gene Name: | PRDM1 |
Uniprot: | O75626 |
Entrez: | 639 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
Beta-interferon gene positive regulatory domain I-binding factor; beta-interferon gene positive-regulatory domain I binding factor; BLIMP1; BLIMP-1; BLIMP1MGC118925; blmp-1; B-lymphocyte-induced maturation protein 1; MGC118922; MGC118923; Positive regulatory domain I-binding factor 1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI-BF1MGC118924; PRDI-binding factor 1; PRDI-binding factor-1; PRDM1; PR-domain zinc finger protein 1; ZNFPR1A1
Mass (kDA):
91.771 kDA
Human | |
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Location: | 6q21 |
Sequence: | 6; NC_000006.12 (106046729..106109938) |
Nucleus. Cytoplasm.
This article will explore the benefits of the PRDM1 marker Functional Analyses of Neonatal Mature B cells, and the validation of the PRDM1 ELISA Kit from Boster Bio. Read on to learn more. You can also find useful resources for this research in our related posts. We hope that you find this information helpful! In the meantime, have fun testing!
A new study has revealed that the PRDM1 marker can be beneficial. The protein acts as a tumor suppressor in lung cancer cells. This marker can be used to help researchers determine the chemotherapy or drugs that are most effective for this condition. It is used in a variety of areas of research into cancer. Here are the advantages of PRDM1 testing. Find out more here. - It is highly specific. It can be used to test the blood of patients suffering from lung cancer.
NK cells that express the PRDM1 gene exhibit a superior response to immunotherapy drugs. PRDM1 knockdown causes increased Apoptosis and better G2/M cell cycle progression in PRDM1 Null NK cell lines. These cells can be targeted to fight cancer more efficiently by targeting PRDM1. Therefore, this type of immunotherapy may benefit patients suffering from various types of cancer.
Adult and neonatal mature B cells express pro-B cells in a subset that differ from those found in embryonic animals. The major germ-line probiotic subset of mature BM is absent in Neonatal B cells. These subsets are distinct in the early stages of their development. A tiny amount of Ia is expressed by pro-B cells from the fetal germ line and the neonatal germ line. This could be due to a lower expression of CD73 which is an important molecular regulator of the immune system.
HLA-DR cells have been identified in neonates within both the adult and neonatal B cell populations. However the neonatal population displayed more proliferative responses. The insoluble anti-IgG antibody ligation resulted in a higher expression of HLA–DR in the neonatal population that was enriched, while anti-dextran did no alter the response to ligation in adult cordblood. The neonatal cord blood cells also showed a positive response to crosslinking of antigen receptors within cord blood samples.
We found that Ia is expressed in the majority of CD4+ pro-B cells. The VHDHJH subset isn't enriched for CD4+ cells. We also found that Ia expression was present in the CD4+ pro-B cells subset, though the frequency was low. We conclude that Ia expression is essential to understanding the B cell's development.
These findings also reveal that CD300 molecules are expressed differently in adults and neonates. Adult B cells expressed the CCR7 and CD62L molecules, however, the latter showed lower levels of expression. Adult CD19+ cells expressed higher levels of CD300a and CD300b. In both donor groups, the inhibitory CD300a receptor was significantly lower than in neonathanthan. While CD300a and CCR7 are present in the blood of neonatal cords, their expression patterns are different from that of adults.
We found that the CCR7 chain is also expressed in neonatal and adult B cell tissues through immunofluorescence. While the IL-2Ra chain was not present in cord blood B cells, it was found in a significant proportion of adult peripheral blood B cells. This difference was attributed to the absence of a preactivated neonatal population. Therefore, there is a major distinction between these two subsets.
CD27dull memory cells are more common in neonates than CD27bright. This may be due to the fact that the human newborn's HCDR3 lengths are less than the lengths of adult B cells. This could lead to infants not receiving as powerful responses. These differences could be due to the composition of the B cell memory compartment.
The pro-B cell subset CD4+ is distinctly different from adult B cells. The CD4+ subset of B cells expresses Ia at lower levels than the CD4+ subset, and the CD8+ subset is absent in neonates. This is consistent with previous research. The results show that adult pro-B cells express Ia. These results show the differences between fetal and adult B cells in this subset.
Boster Bio PRDM1 ELISA tests are developed with accuracy and precision in mind. Boster Bio's rigorous validation program ensures the highest quality of their kits. To ensure that their kits provide exact results, Boster conducts dilution series which show the dynamic range of the assay. Each sample was serially diluted to produce results that were within the range expected.
Boster Bio Anti-PRDM1 The antibody BLIMP1 is part of Picoband(tm). It has been tested in WB and IP for Human, Mouse and Rat. Boster Bio PRDM1-BLIMP1 antibody made from rabbit serum. It is highly recommended that an BLIMP1 ELISA kit be tested before putting it into clinical use.
PMID: 1851123 by Keller A.D., et al. Identification and characterization of a novel repressor of beta- interferon gene expression.
PMID: 12626569 by Gyory I., et al. Identification of a functionally impaired positive regulatory domain I binding factor 1 transcription repressor in myeloma cell lines.