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- Table of Contents
Bloom syndrome protein Antibodies
AND BLM ELISA kits, Bloom syndrome protein Proteins
Many biological assays use antibodies to detect Bloom syndrome protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bloom syndrome protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bloom syndrome protein antibodies...
Designing an IHC experiment for Bloom syndrome protein? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the BLM IHC GuideBLM Infographic by Boster Bio
All BLM Products
Product
Figures
Specificity
Applications
Price
Anti-RMI2 Antibody Picoband®
1 Citations
Human, Mouse, Rat
Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # A08685
100 μg/vial
Cat # A08685
100 μg/vial
Human, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A08709-2
100 μg/vial
Cat # A08709-2
100 μg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A08699-1
100 µg/vial
Cat # A08699-1
100 µg/vial
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A08692-1
100 μg/vial
Cat # A08692-1
100 μg/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2032
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2032
1 kit, containing two 96-well plates and all necessary reagents
Enzyme Activity, SDS-PAGE
$250
Cat # PROTQ13867
Starting from 20ug
Cat # PROTQ13867
Starting from 20ug
BLM Overview
Facts about Bloom syndrome protein.
Bloom syndrome protein (BLM)
ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288).
Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030).
Gene Information
| Human | |
|---|---|
| Gene Name: | BLM |
| Uniprot: | P54132 |
| Entrez: | 641 |
Family
| Belongs to: |
|---|
| helicase family |
Alternative Names
Bloom syndrome; Bloom syndrome, RecQ helicase-like; BSBloom syndrome protein; DNA helicase, RecQ-like type 2; EC 3.6.1; EC 3.6.4.12; MGC126616; MGC131618; RecQ protein-like 3; RecQ2; RECQ2MGC131620; RECQL3RECQL2
Molecular Weight
Mass (kDA):
159 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q26.1 |
| Sequence: | 15; NC_000015.10 (90717346..90816166) |
Subcellular Localizations
Nucleus. Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.
Diseases
- Malignant Neoplasms
- Neoplasms
- Fibrosis
- Pulmonary Fibrosis
- Bloom Syndrome
- Carcinoma
- Genomic Instability
- Lung Injury
- Malignant Squamous Cell Neoplasm
- Werner Syndrome
- Inflammation
- Pneumonia
- Neoplasm Metastasis
Interacting Proteins
- BRIP1
- FEN1
- NABP2
- PLK1
- RAD51D
- RMI1
- RPA1
- RPS27
- TERF1
- TERF2
Pathways
- Transport
- Dna Repair
- Dna Replication
- Cell Cycle
- Localization
- Aging
- Pathogenesis
- Secretion
- Cell Proliferation
- Cell Death
- Mitosis
- S Phase
- Cell Growth
PTMs
- Cleavage
- Phosphorylation
- Oxidation
- Reduction
- Sumoylation
- Biotinylation
- Dephosphorylation
- Methylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Core ESC-Like Genes
- DNA Repair
- Genes Sensitive to DNA Damaging Agents
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/BLM
bosterbio.com/bosterbio-gene-info-cards/BLM
References
PMID: 7585968 by Ellis N.A., et al. The Bloom's syndrome gene product is homologous to RecQ helicases.
PMID: 9388193 by Karow J.K., et al. The Bloom's syndrome gene product is a 3'-5' DNA helicase.
1 Publications of Boster Bloom syndrome protein Antibodies & ELISA Kits
- PubMed ID: 10.1159/000453192, Bleomycin Suppresses the Proliferation and the Mobility of Human Gastric Cancer ...
*More publications can be found for each product on its corresponding product page