Bloom syndrome protein Antibodies

AND BLM ELISA kits, Bloom syndrome protein Proteins

Many biological assays use antibodies to detect Bloom syndrome protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Bloom syndrome protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Bloom syndrome protein antibodies...

We validate the specificity of these antibodies to Bloom syndrome protein by testing them on tissues known to express BLM positively and negatively. Browse below to find the BLM antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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BLM Infographic by Boster Bio

All BLM Products

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Anti-Phospho-BLM (T99) Antibody

Western blot analysis of lysates from HepG2 cells, using Bloom Syndrome (Phospho-Thr99) Antibody

Immunohistochemistry analysis of paraffin-embedded human heart, using Bloom Syndrome (Phospho-Thr99) Antibody

Immunofluorescence analysis of HeLa cells, using Bloom Syndrome (Phospho-Thr99) Antibody

Human, Mouse, Rat

ELISA, IF, IHC, WB

$380
Cat # A00724T99
100ul

Anti-Bloom syndrome protein BLM Antibody

Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using Bloom Syndrome Antibody

Immunofluorescence analysis of A549 cells, using Bloom Syndrome Antibody

Human, Mouse

ELISA, IF, IHC

$380
Cat # A00724
100ul

Anti-Fruit fly Blm Antibody

Fruit fly

$470
Cat # DZ41293
200 μl/vial

BLM Overview

Facts about Bloom syndrome protein.

BLM 3D structure. Source: alphafold

Bloom syndrome protein (BLM)

ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030). Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288).

Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134). Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030).

Gene Information

Human
Gene Name:	BLM
Uniprot:	P54132
Entrez:	641

Family

Belongs to:

helicase family

Alternative Names

Bloom syndrome; Bloom syndrome, RecQ helicase-like; BSBloom syndrome protein; DNA helicase, RecQ-like type 2; EC 3.6.1; EC 3.6.4.12; MGC126616; MGC131618; RecQ protein-like 3; RecQ2; RECQ2MGC131620; RECQL3RECQL2

Molecular Weight

Mass (kDA):
159 kDA

Genomic Context


Human

Location:	15q26.1
Sequence:	15; NC_000015.10 (90717346..90816166)

Subcellular Localizations

Nucleus. Together with SPIDR, is redistributed in discrete nuclear DNA damage-induced foci following hydroxyurea (HU) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a RMI complex- and SPIDR-dependent manner.