This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
PRKAB2 Antibodies
AND PRKAB2 ELISA kits, PRKAB2 Proteins
Many biological assays use antibodies to detect PRKAB2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKAB2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKAB2 antibodies...
Designing a Western blot for PRKAB2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the PRKAB2 Western Blot GuideDesigning an IHC experiment for PRKAB2? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PRKAB2 IHC GuidePRKAB2 Infographic by Boster Bio
All PRKAB2 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9739
100 μg/vial
Cat # PB9739
100 μg/vial
Human
Flow Cytometry, IHC, WB
$370
Cat # M05234
100 μg/vial
Cat # M05234
100 μg/vial
Human
Flow Cytometry, IHC, ICC, WB
$370
Cat # M05077
100 μg/vial
Cat # M05077
100 μg/vial
PRKAB2 Overview
Facts about 5'-AMP-activated protein kinase subunit beta-2.
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation.
AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRKAB2 |
| Uniprot: | O43741 |
| Entrez: | 5565 |
Family
| Belongs to: |
|---|
| 5'-AMP-activated protein kinase beta subunit family |
Alternative Names
5'-AMP-activated protein kinase, beta-2 subunit; AMPK beta 2; AMPK beta 2,5'-AMP-activated protein kinase subunit beta-2; AMPK beta-2 chain; AMPK subunit beta-2; MGC61468; PRKAB2; protein kinase, AMP-activated, beta 2 non-catalytic subunit
Molecular Weight
Mass (kDA):
30.302 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q21.1 |
| Sequence: | 1; NC_000001.11 (147155106..147173366, complement) |
Diseases
- Diabetes Mellitus
- Diabetes Mellitus, Non-insulin-dependent
- Malignant Neoplasms
- Insulin Sensitivity
- Ischemia
- Heart Diseases
- Insulin Resistance
- Obesity
- Schizoaffective Disorder
- Malignant Neoplasm Of Breast
- Subaortic Stenosis
- Hypoxia
Pathways
- Energy Homeostasis
- Transport
- Protein Transport
- Cell Cycle Arrest
- Response To Ischemia
- Senescence
- Drug Resistance
- Lipid Oxidation
- Endoplasmic Reticulum Unfolded Protein Response
- Cell Cycle
- Protein Folding
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKAB2
bosterbio.com/bosterbio-gene-info-cards/PRKAB2
References
PMID: 9575201 by Thornton C., et al. Identification of a novel AMP-activated protein kinase beta subunit isoform that is highly expressed in skeletal muscle.
PMID: 12490143 by Prochazka M., et al. Variant screening of PRKAB2, a type 2 diabetes mellitus susceptibility candidate gene on 1q in Pima Indians.