- Table of Contents
RORA is triggered by phosphorylation. Required for sugar - mediated adipogenic differentiation growth and osteogenic differentiation inhibition from osteoblasts.
|protein kinase superfamily|
|Sequence:||19; NC_000019.10 (14091688..14117762, complement)|
Isoform 1 is ubiquitous. Isoform 2 is sperm- specific and is enriched in pachytene spermatocytes but is not detected in round spermatids.
Cytoplasm. Cell membrane. Nucleus. Mitochondrion. Membrane; Lipid-anchor. Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). Colocalizes with HSF1 in nuclear stress bodies (nSBs) upon heat shock (PubMed:21085490).; [Isoform 2]: Cell projection, cilium, flagellum. Cytoplasmic vesicle, secretory vesicle, acro