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- Table of Contents
Alternative prion protein Antibodies
AND PRNP ELISA kits, Alternative prion protein Proteins
Many biological assays use antibodies to detect Alternative prion protein, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Alternative prion protein in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Alternative prion protein antibodies...
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PRNP Infographic by Boster Bio
All PRNP Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9783
100 μg/vial
Cat # PB9783
100 μg/vial
Anti-Prion protein PrP/PRNP Antibody Picoband®
1 Citations 16 Q&As
Mouse, Rat
IHC, WB
$370
Cat # PA1795
100 μg/vial
Cat # PA1795
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M02447
100 μl
Cat # M02447
100 μl
PRNP Overview
Facts about Alternative prion protein.
Alternative prion protein (PRNP)
Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity.
Might be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor.
Gene Information
| Human | |
|---|---|
| Gene Name: | PRNP |
| Uniprot: | F7VJQ1 |
| Entrez: | 5621 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
CD230; CJD; fatal familial insomnia); GSS; prion protein (p27-30); prion protein PrP; prion protein; prion-related protein; PRIPMGC26679
Molecular Weight
Mass (kDA):
8.691 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20p13 |
| Sequence: | 20; NC_000020.11 (4686456..4701588) |
Tissue Specificity
Detected in brain homogenate, primary neurons, and peripheral blood mononuclear cells (at protein level).
Subcellular Localizations
Mitochondrion outer membrane; Single-pass membrane protein.
Diseases
- Prion Diseases
- Creutzfeldt-jakob Disease
- Encephalopathies
- Scrapie
- Encephalopathy, Bovine Spongiform
- Neurodegenerative Disorders
- Dementia
- Alzheimer's Disease
- Sporadic Cjd
- New Variant Creutzfeldt-jakob Disease
- Sleeplessness
- Ataxia
Pathways
- Pathogenesis
- Cell Death
- Glycosylation
- Localization
- Immune Response
- Secretion
- Neuroprotection
- Synaptic Transmission
- Transport
- Rna Interference
- Amyloid Fibril Formation
- Cell Adhesion
- Cell Differentiation
PTMs
- Glycosylation
- Cleavage
- Phosphorylation
- Gpi Anchoring
- Deglycosylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRNP
bosterbio.com/bosterbio-gene-info-cards/PRNP
References
PMID: 21478263 by Vanderperre B., et al. An overlapping reading frame in the PRNP gene encodes a novel polypeptide distinct from the prion protein.
1 Publications of Boster Alternative prion protein Antibodies & ELISA Kits
- PubMed ID: 10.1096/fj.201601042RR, Pseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloi...
*More publications can be found for each product on its corresponding product page