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- Table of Contents
Facts about Prostaglandin E2 receptor EP4 subtype.
Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
| Human | |
|---|---|
| Gene Name: | PTGER4 |
| Uniprot: | P35408 |
| Entrez: | 5734 |

| Belongs to: |
|---|
| G-protein coupled receptor 1 family |

EP4; EP4R; MGC126583; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; Prostanoid EP4 receptor; PTGER2; PTGER4
Mass (kDA):
53.119 kDA

| Human | |
|---|---|
| Location: | 5p13.1 |
| Sequence: | 5; NC_000005.10 (40679915..40740936) |
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Cell membrane; Multi-pass membrane protein.





PMID: 8163486 by Bastien L., et al. Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype.
PMID: 8250933 by An S., et al. Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2.