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- Table of Contents
PTGFR Antibodies
AND PTGFR ELISA kits, PTGFR Proteins
Many biological assays use antibodies to detect PTGFR, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTGFR in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTGFR antibodies...
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PTGFR Infographic by Boster Bio
All PTGFR Products
Product
Figures
Specificity
Applications
Price
Human
$628
Cat # LS005737
20 µg, 100 µg
Cat # LS005737
20 µg, 100 µg
PTGFR Overview
Facts about Prostaglandin F2-alpha receptor.
Prostaglandin F2-alpha receptor (PTGFR)
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
Gene Information
| Human | |
|---|---|
| Gene Name: | PTGFR |
| Uniprot: | P43088 |
| Entrez: | 5737 |
Family
| Belongs to: |
|---|
| G-protein coupled receptor 1 family |
Alternative Names
FP; MGC120498; MGC46203; PGF receptor; PGF2 alpha receptor; PGF2-alpha Receptor; prostaglandin F receptor (FP); prostaglandin F2 alpha receptor; prostaglandin F2-alpha receptor; prostaglandin receptor (2-alpha); Prostanoid FP receptor; PTGFR
Molecular Weight
Mass (kDA):
40.055 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p31.1 |
| Sequence: | 1; NC_000001.11 (78490974..78540701) |
Tissue Specificity
Eye.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein.
Diseases
- Premature Obstetric Labor
- Malignant Neoplasms
- Neoplasms
- Dysequilibrium Syndrome
- Tissue Adhesions
- Neoplasm Metastasis
- Fracture Of First Cervical Vertebra
- Extravasation
- Malignant Neoplasm Of Breast
- Glaucoma, Open-angle
- Endometrial Polyp
- Infertility
- Abnormal Coordination
Pathways
- Parturition
- Luteolysis
- Localization
- Ovulation
- Pathogenesis
- Cell Adhesion
- Cell Activation
- Endothelial Cell Activation
- Reproductive Process
- Cell Development
- Immune Response
- Neutrophil Extravasation
PTMs
- Disulfide bond
Research Areas
- GPCR
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTGFR
bosterbio.com/bosterbio-gene-info-cards/PTGFR
References
PMID: 8300593 by Abramovitz M., et al. Cloning and expression of a cDNA for the human prostanoid FP receptor.
PMID: 9341156 by Kunapuli P., et al. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso- PGF2alpha.