Ras-related protein Rab-1B (Rab1b)

The little GTPases Rab are crucial regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an energetic GTP-bound form that is able to recruit to membranes distinct pair of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion.

RAB1B regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Plays a role in the initial events of the autophagic vacuole development that occur at specialized regions of the endoplasmic reticulum.