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RAD23B Antibodies
AND RAD23B ELISA kits, RAD23B Proteins
Many biological assays use antibodies to detect RAD23B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAD23B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAD23B antibodies...
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RAD23B Overview
Facts about UV excision repair protein RAD23 homolog B.
UV excision repair protein RAD23 homolog B (RAD23B)
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains.
Proposed to be able to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAD23B |
| Uniprot: | P54727 |
| Entrez: | 5887 |
Family
| Belongs to: |
|---|
| RAD23 family |
Alternative Names
HHR23B; HR23BUV excision repair protein RAD23 homolog B; P58; RAD23 (S. cerevisiae) homolog B; RAD23 homolog B (S. cerevisiae); RAD23, yeast homolog of, B; XP-C repair complementing complex 58 kDa; XP-C repair complementing protein; XP-C repair-complementing complex 58 kDa protein
Molecular Weight
Mass (kDA):
43.171 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q31.2 |
| Sequence: | 9; NC_000009.12 (107283279..107332194) |
Subcellular Localizations
Nucleus. Cytoplasm. The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin.
Diseases
- Malignant Neoplasms
- Xeroderma Pigmentosum
- Xeroderma
- Xeroderma Pigmentosum, Complementation Group C
- Neoplasms
- Carcinoma
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Ataxia
- Liver Carcinoma
- Machado-joseph Disease
- Liver Neoplasms
- Neurodegenerative Disorders
Interacting Proteins
- ADRM1
- ERCC3
- NGLY1
- Pax3
- PNMA5
- PSMD4
- PUF60
- UBA3
- UBB
- UBC
Pathways
- Dna Repair
- Proteolysis
- Cell Cycle
- Cell Death
- Localization
- Aging
- Spermatogenesis
- Cell Division
- Cell Communication
- Rna Interference
- Cell Activation
- Gene Silencing
- Dna Hypermethylation
PTMs
- Ubiquitination
- Cleavage
- Demethylation
Research Areas
- Apoptosis
- Cancer
- Core ESC-Like Genes
- DNA Repair
- Nucleotide Excision Repair
- Stem Cell Markers
- Tumor Suppressors
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAD23B
bosterbio.com/bosterbio-gene-info-cards/RAD23B
References
PMID: 8168482 by Masutani C., et al. Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23.
PMID: 15064313 by Huang X., et al. Expression of a novel RAD23B mRNA splice variant in the human testis.