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- Table of Contents
RAP1A Antibodies
AND RAP1A ELISA kits, RAP1A Proteins
Many biological assays use antibodies to detect RAP1A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAP1A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAP1A antibodies...
Designing a Western blot for RAP1A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RAP1A Western Blot GuideRAP1A Infographic by Boster Bio
All RAP1A Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IP, WB
$370
Cat # M01848
100 μl/vial
Cat # M01848
100 μl/vial
Human, Mouse, Rat
ELISA
$540
Cat # EKC2539
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2539
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2538
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2538
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2133
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2133
1 kit, containing two 96-well plates and all necessary reagents
RAP1A Overview
Facts about Ras-related protein Rap-1A.
Ras-related protein Rap-1A (RAP1A)
Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner.
Together with ITGB1BP1, modulates KRIT1 localization into microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth.
Gene Information
| Human | |
|---|---|
| Gene Name: | RAP1A |
| Uniprot: | P62834 |
| Entrez: | 5906 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
C21KG; G-22K; GTP-binding protein smg p21A; KREV-1; KREV1Ras-related protein Krev-1; RAP1; Rap1A; RAP1A, member of RAS oncogene family; RAS-related protein RAP1A; ras-related protein Rap-1A; SMGP21
Molecular Weight
Mass (kDA):
20.987 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1p13.2 |
| Sequence: | 1; NC_000001.11 (111542009..111716695) |
Subcellular Localizations
Cell membrane; Lipid-anchor. Cytoplasm. Cytoplasm, perinuclear region. Cell junction. Early endosome. Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region.
Diseases
- Malignant Neoplasms
- Tissue Adhesions
- Neoplasms
- Leukemia
- Neoplasm Metastasis
- Cell Transformation, Neoplastic
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Cavernous Hemangioma Of Brain
- Tumor Angiogenesis
Interacting Proteins
- RAF1
- Rassf5
Pathways
- Prenylation
- Localization
- Cell Adhesion
- Cell Proliferation
- Integrin Activation
- Cell Cycle
- Protein Prenylation
- Pathogenesis
- Cell Growth
- Bone Resorption
- Cell Migration
- Angiogenesis
- Cell Death
PTMs
- Prenylation
- Phosphorylation
- Farnesylation
- Geranylgeranylation
- Formylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAP1A
bosterbio.com/bosterbio-gene-info-cards/RAP1A
References
PMID: 3045729 by Pizon V., et al. Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.
PMID: 2507536 by Nagata K., et al. Purification, identification, and characterization of two GTP-binding proteins with molecular weights of 25,000 and 21,000 in human platelet cytosol. One is the rap1/smg21/Krev-1 protein and the other is a novel GTP-binding protein.