Proto-oncogene c-Rel Antibodies

Proto-oncogene c-Rel (REL)

NF-kappa-B is a pleiotropic transcription factor that's present in almost all cell types and is involved in several biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52.

The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites which they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Gene Information

Human
Gene Name:	REL
Uniprot:	Q04864
Entrez:	5966

Family

Belongs to:
No superfamily

Alternative Names

C-Rel proto-oncogene protein; cRel; c-Rel; I-Rel; oncogene REL, avian reticuloendotheliosis; proto-oncogene c-Rel; REL; v-rel avian reticuloendotheliosis viral oncogene homolog; v-rel reticuloendotheliosis viral oncogene homolog (avian)

Molecular Weight

Mass (kDA):
68.52 kDA

Genomic Context

Human
Location:	2p16.1
Sequence:	2; NC_000002.12 (60881521..60931612)

Subcellular Localizations

Nucleus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Inflammation
• Cell Transformation, Neoplastic
• Leukemia
• Lymphoma
• Tissue Adhesions
• Hiv Infections
• Immunologic Deficiency Syndromes
• Rheumatic Heart Disease
• Carcinoma
• Innate Immune Response

• Leukemia, T-cell
• Malignant Paraganglionic Neoplasm
• Reticuloendothelial Hyperplasia
• Autoimmune Reaction
• Infective Disorder
• Autoimmune Diseases
• Hyperplasia

Pathways

• Localization
• Immune Response
• Cell Death
• Cell Proliferation
• Pathogenesis
• Cell Growth
• Cell Cycle
• Oncogenesis
• Secretion
• Proteolysis
• Translation
• Transport
• Nuclear Import

• Cell Activation
• Programmed Cell Death
• Cytokine Production
• Cell Differentiation
• Cell Development
• Cell Adhesion
• T Cell Activation

PTMs

• Phosphorylation
• Cleavage
• Ubiquitination
• Phosphorothioation
• Acetylation
• Dephosphorylation
• Reduction
• Methylation

• Oxidation
• Nitrosylation
• Nitration
• Biotinylation
• Hydroxylation
• Acylation
• Prenylation
• Deacetylation

• Myristoylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/REL

Best Uses Of The REL Marker From Boster Bio

If you're searching for the best marker for PLG, you've reached the right place. This article will discuss Boster Bio’s PLG Marker as well as Boster Bio’s Anti-MacrosialinCD68 Antibody. You can learn more about these products by reading the following. These products can improve your life in many ways.

Boster Bio PLG Marker

Boster Bio PLGMarker is an innovative biomaterial that can encapsulate CpG or bacterial antibodies. Scientists can submit their findings and receive product credits. This service is available worldwide to all scientists. This article will present an overview of Boster Bio PLGMarker's best use. This article will also provide an overview about the Boster Bio's features, and its benefits.

Boster Bio Anti-Macrosialin CD68 Antibody

Boster Bio AntiMacrosialInCD68 Monoclonal Monoclonal Monoclonal MonoclonalAntibody recognizes the CD68 protein. It is approved for IHC–P application. This antibody reacts also with Human, Rat, and Mouse samples. It is non-immune-specific and does not block tetracytokines.

The protein is highly glycosylated and is an integral part of the membrane protein. It is closely related to Lysosomal/endosomal (LAMP) Glycoproteins. CD68 is widely used as a pan-macrophage marker and is present in low levels on Langerhans cells and conventional dendritic cells. CD68 is found mainly in late endosomes and lysosomes, with only a small fraction circulating at the cell surface. Cell stimulation can induce it, which results in glycoform remodeling and transport to cells surface.

CD68 is a 110 kDa membrane glycoprotein. It belongs to the LAMP (lysosomal-associated membrane protein) family and plays an important role in macrophage recruitment and activation. It is located primarily in the lysosome, but can also be found on the cell surface. However, it is thought that CD68 has a role in atherosclerosis.

Boster Bio Anti-Macrosial Inate Receptor (REL Marker) binds specifically to tissue lectins, and targets tumor cell. It is an excellent tool for studying the immune response to tumor cells in vitro. It is highly recommended for all immunohistochemical studies of cancer cells. Boster Bio Anti-Macrosialin CD68 Monoclonal Antibody uses REL marker and is highly precise.