RETSAT Antibodies

AND RETSAT ELISA kits, RETSAT Proteins

Many biological assays use antibodies to detect RETSAT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RETSAT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RETSAT antibodies...

We validate the specificity of these antibodies to RETSAT by testing them on tissues known to express RETSAT positively and negatively. Browse below to find the RETSAT antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RETSAT Infographic by Boster Bio

All RETSAT Products

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Anti-RETSAT Antibody Picoband®

Western blot analysis of RETSAT using anti-RETSAT antibody (A11393)

Flow Cytometry analysis of HepG2 cells using anti-RETSAT antibody (A11393)

Human, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A11393
100 µg/vial

RETSAT Overview

Facts about All-trans-retinol 13,14-reductase.

RETSAT 3D structure. Source: alphafold

All-trans-retinol 13,14-reductase (RETSAT)

Catalyzes the saturation of all-trans-retinol to all- trans-13,14-dihydroretinol. Does not exhibit any action toward all-trans-retinoic acid, nor 9-cis, 11-cis or 13-cis-retinol isomers.

May play a role in the metabolism of vitamin A. Independently of retinol conversion, may regulate liver metabolism of MLXIPL/ChREBP.

Gene Information

Human
Gene Name:	RETSAT
Uniprot:	Q6NUM9
Entrez:	54884

Family

Belongs to:

carotenoid/retinoid oxidoreductase family

Alternative Names

All-trans-13,14-dihydroretinol saturase; all-trans-retinol 13,14-reductase; EC 1.3.99.23; FLJ20296; retinol saturase (all-trans-retinol 13,14-reductase); RetSat

Molecular Weight

Mass (kDA):
66.82 kDA

Genomic Context


Human

Location:	2p11.2
Sequence:	2; NC_000002.12 (85341955..85354528, complement)

Tissue Specificity

Expressed in liver; expression positively correlates with obesity and liver steatosis (PubMed:28855500). Expressed in adipose tissue; expression tends to be decreased in obese versus lean individuals (PubMed:19139408).

Subcellular Localizations

Endoplasmic reticulum membrane; Peripheral membrane protein.

Diseases

Metabolic Diseases
Insulin Resistance
Diabetes Mellitus, Non-insulin-dependent
Chronic Metabolic Disorder
Obesity
Refractory Anemia With Ringed Sideroblasts

Diabetes Mellitus

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RETSAT

References

PMID: 19139408 by Schupp M., et al. Retinol saturase promotes adipogenesis and is downregulated in obesity.

PMID: 28855500 by Heidenreich S., et al. Retinol saturase coordinates liver metabolism by regulating ChREBP activity.