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- Table of Contents
Facts about Sterol regulatory element-binding protein cleavage-activating protein.
Formation of a ternary complex with INSIG at high sterol concentrations leads to masking of an ER-export signal in SCAP and retention of the complex in the ER. Low sterol concentrations activate release of INSIG, a conformational change in the SSC domain of SCAP, unmasking of the ER export signal, recruitment into COPII-coated vesicles, transfer to the Golgi complex, proteolytic cleavage of SREBF in the Golgi, launch of this transcription factor fragment of SREBF from the membrane, its import into the nucleus and up-regulation of LDLR, INSIG1 and the mevalonate pathway (By similarity).
Human | |
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Gene Name: | SCAP |
Uniprot: | Q12770 |
Entrez: | 22937 |
Belongs to: |
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WD repeat SCAP family |
KIAA0199; PSEC0227; SREBF chaperone; SREBP cleavage-activating protein; sterol regulatory element binding protein cleavage-activating protein
Mass (kDA):
139.729 kDA
Human | |
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Location: | 3p21.31 |
Sequence: | 3; NC_000003.12 (47413681..47477126, complement) |
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Moves from the endoplasmic reticulum to the Golgi in the absence of sterols.
PMID: 10570913 by Nakajima T., et al. Genomic structure and chromosomal mapping of the human sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) gene.
PMID: 15133039 by Heemers H., et al. Identification of an androgen response element in intron 8 of the sterol regulatory element-binding protein cleavage-activating protein gene allowing direct regulation by the androgen receptor.