SCN4B Antibodies

AND SCN4B ELISA kits, SCN4B Proteins

Many biological assays use antibodies to detect SCN4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCN4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCN4B antibodies...

We validate the specificity of these antibodies to SCN4B by testing them on tissues known to express SCN4B positively and negatively. Browse below to find the SCN4B antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SCN4B? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SCN4B Western Blot Guide

Designing an IHC experiment for SCN4B? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.

Open the SCN4B IHC Guide

SCN4B Infographic by Boster Bio

All SCN4B Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-SCN4B Antibody Picoband®

IHC analysis of SCN4B using anti-SCN4B antibody (A06453-1)

Western blot analysis of SCN4B using anti-SCN4B antibody (A06453-1)

Human, Mouse, Rat

Flow Cytometry, IHC, IHC-F, ICC, WB

$370
Cat # A06453-1
100 μg/vial

Anti-IL-18R Beta/IL-18RAP Antibody Picoband®

Western blot analysis of IL-18R Beta/IL-18RAP using anti-IL-18R Beta/IL-18RAP antibody (A06457-2)

Human

$370
Cat # A06457-2
100 μg/vial

SCN4B (NM_174934) Human Over-expression Lysate

Human

$628
Cat # LS006330
20 µg, 100 µg

SCN4B (NM_174934) Human Recombinant Protein

Coomassie blue staining of purified SCN4B protein

$1062
Cat # PROTQ8IWT1
20 µg

SCN4B Overview

Facts about Sodium channel subunit beta-4.

SCN4B 3D structure. Source: alphafold

Sodium channel subunit beta-4 (SCN4B)

Modulates channel gating kinetics. Causes adverse impacts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.

Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. .

Gene Information

Human
Gene Name:	SCN4B
Uniprot:	Q8IWT1
Entrez:	6330

Family

Belongs to:

sodium channel auxiliary subunit SCN4B (TC 8.A.17) family

Alternative Names

sodium channel beta-4 subunit; sodium channel subunit beta-4; sodium channel, voltage-gated, type IV, beta

Molecular Weight

Mass (kDA):
24.969 kDA

Genomic Context


Human

Location:	11q23.3
Sequence:	11; NC_000011.10 (118133377..118152823, complement)

Tissue Specificity

Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.

Subcellular Localizations

Cell membrane; Single-pass type I membrane protein.

Diseases

Cardiac Arrhythmia
Long Qt Syndrome
Brugada Syndrome (disorder)
Channelopathies
Alzheimer's Disease
Cardiac Death
Pain Syndrome
Sudden Infant Death Syndrome
Erythromelalgia
Pain
Cardiac Arrest

Sudden Cardiac Death
Syncope
Atrial Fibrillation
Malignant Paraganglionic Neoplasm
Cardiac Fibrillation
Tachycardia, Ventricular

Pathways

Pathogenesis
Cardiac Conduction
Cell Adhesion
Protein Glycosylation
Membrane Repolarization
Cell Development
Glycosylation
Synaptic Transmission

Hypersensitivity
Blood Circulation
Localization

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCN4B

References

PMID: 12930796 by Yu F.H., et al. Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.

PMID: 24297919 by Gilchrist J., et al. Crystallographic insights into sodium-channel modulation by the beta4 subunit.