This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
SCN4B Antibodies
AND SCN4B ELISA kits, SCN4B Proteins
Many biological assays use antibodies to detect SCN4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCN4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCN4B antibodies...
Previous: CBLIF
Next: SCN7A
SCN4B Infographic by Boster Bio
All SCN4B Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, IF, IHC, WB
$399
Cat # A06453
100μl
Cat # A06453
100μl
Human, Mouse, Rat
Flow Cytometry, IHC, IHC-F, ICC, WB
$370
Cat # A06453-1
100 μg/vial
Cat # A06453-1
100 μg/vial
SCN4B Overview
Facts about Sodium channel subunit beta-4.
Sodium channel subunit beta-4 (SCN4B)
Modulates channel gating kinetics. Causes adverse impacts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation.
Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SCN4B |
| Uniprot: | Q8IWT1 |
| Entrez: | 6330 |
Family
| Belongs to: |
|---|
| sodium channel auxiliary subunit SCN4B (TC 8.A.17) family |
Alternative Names
sodium channel beta-4 subunit; sodium channel subunit beta-4; sodium channel, voltage-gated, type IV, beta
Molecular Weight
Mass (kDA):
24.969 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q23.3 |
| Sequence: | 11; NC_000011.10 (118133377..118152823, complement) |
Tissue Specificity
Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
Subcellular Localizations
Cell membrane; Single-pass type I membrane protein.
Diseases
- Cardiac Arrhythmia
- Long Qt Syndrome
- Brugada Syndrome (disorder)
- Channelopathies
- Alzheimer's Disease
- Cardiac Death
- Pain Syndrome
- Sudden Infant Death Syndrome
- Erythromelalgia
- Pain
- Cardiac Arrest
Pathways
- Pathogenesis
- Cardiac Conduction
- Cell Adhesion
- Protein Glycosylation
- Membrane Repolarization
- Cell Development
- Glycosylation
- Synaptic Transmission
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCN4B
bosterbio.com/bosterbio-gene-info-cards/SCN4B
References
PMID: 12930796 by Yu F.H., et al. Sodium channel beta4, a new disulfide-linked auxiliary subunit with similarity to beta2.
PMID: 24297919 by Gilchrist J., et al. Crystallographic insights into sodium-channel modulation by the beta4 subunit.