Anti-Sodium channel subunit beta-4 Scn4b Antibody

SCN4B antibody

Boster Bio Anti-Sodium channel subunit beta-4 Scn4b Antibody catalog # A06453. Tested in WB applications. This antibody reacts with Human.

Product Info Summary

SKU: A06453
Size: 100μl
Reactive Species: Human
Host: Rabbit
Application: WB

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Product Name

Anti-Sodium channel subunit beta-4 Scn4b Antibody

View all SCN4B Antibodies

SKU/Catalog Number

A06453

Size

100μl

Form

Liquid

Description

Boster Bio Anti-Sodium channel subunit beta-4 Scn4b Antibody catalog # A06453. Tested in WB applications. This antibody reacts with Human.

Storage & Handling

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Cite This Product

Anti-Sodium channel subunit beta-4 Scn4b Antibody (Boster Biological Technology, Pleasanton CA, USA, Catalog # A06453)

Host

Rabbit

Contents

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Clonality

Polyclonal

Clone Number

6C12

Isotype

IgG

Immunogen

Synthesized peptide derived from the Internal region of human Scn4b. at AA rangle: 30-110

*Blocking peptide can be purchased. Costs vary based on immunogen length. Contact us for pricing.

Reactive Species

A06453 is reactive to SCN4B in Human

Applications

A06453 is guaranteed for WB Boster Guarantee

Observed Molecular Weight

39 kDa

Calculated molecular weight

24.969kDa

Background of SCN4B

This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Microtubules are polymers of tubulin, which exist as heterodimers of alpha-tubulin and beta-tubulin. NEDD1 (neural precursor expressed, developmentally down-regulated protein1; also called GCP-WD) is a centrosomal protein that in mammals associates with the gamma-tubulin ring complex. Gamma-TuRC is critical for initiation, or nucleation, of the microtubule assembly. In association with this complex, NEDD1 plays an important role in targeting the gamma-TuRC complex to the site of microtubule nucleation and to the mitotic spindle. These events are essential for proper bipolar spindle formation and mitotic progression. Given the casual link between improper spindle function and tumorigenesis, characterization of Nedd1 function will be important to better understand various mechanisms underlying mitotic regulation, chromosome segregation, and cancer development.

Antibody Validation

Boster validates all antibodies on WB, IHC, ICC, Immunofluorescence, and ELISA with known positive control and negative samples to ensure specificity and high affinity, including thorough antibody incubations.

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Assay Dilutions Recommendation

The recommendations below provide a starting point for assay optimization. The actual working concentration varies and should be decided by the user.

WB, 1:500-1:2000

Validation Images & Assay Conditions

Gene/Protein Information For SCN4B (Source: Uniprot.org, NCBI)

Gene Name

SCN4B

Full Name

Sodium channel subunit beta-4

Weight

24.969kDa

Superfamily

sodium channel auxiliary subunit SCN4B (TC 8.A.17) family

Alternative Names

sodium channel beta-4 subunit; sodium channel subunit beta-4; sodium channel, voltage-gated, type IV, beta SCN4B ATFB17, LQT10, Navbeta4 sodium voltage-gated channel beta subunit 4 sodium channel subunit beta-4|sodium channel, voltage-gated, type IV, beta subunit

*If product is indicated to react with multiple species, protein info is based on the gene entry specified above in "Species".

For more info on SCN4B, check out the SCN4B Infographic

SCN4B infographic

We have 30,000+ of these available, one for each gene! Check them out.

In this infographic, you will see the following information for SCN4B: database IDs, superfamily, protein function, synonyms, molecular weight, chromosomal locations, tissues of expression, subcellular locations, post-translational modifications, and related diseases, research areas & pathways. If you want to see more information included, or would like to contribute to it and be acknowledged, please contact [email protected].

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3 Customer Q&As for Anti-Sodium channel subunit beta-4 Scn4b Antibody

Question

I am interested in to test anti-Scn4b antibody A06453 on human brain for research purposes, then I may be interested in using anti-Scn4b antibody A06453 for diagnostic purposes as well. Is the antibody suitable for diagnostic purposes?

Verified Customer

Verified customer

Asked: 2020-02-11

Answer

The products we sell, including anti-Scn4b antibody A06453, are only intended for research use. They would not be suitable for use in diagnostic work. If you have the means to develop a product into diagnostic use, and are interested in collaborating with us and develop our product into an IVD product, please contact us for more discussions.

Boster Scientific Support

Answered: 2020-02-11

Question

I was wanting to use your anti-Scn4b antibody for WB for human brain on frozen tissues, but I want to know if it has been tested for this particular application. Has this antibody been tested and is this antibody a good choice for human brain identification?

Verified Customer

Verified customer

Asked: 2019-05-17

Answer

You can see on the product datasheet, A06453 anti-Scn4b antibody has been validated for WB on human tissues. We have an innovator award program that if you test this antibody and show it works in human brain in IHC-frozen, you can get your next antibody for free.

Boster Scientific Support

Answered: 2019-05-17

Question

Does A06453 anti-Scn4b antibody work on parafin embedded sections? If so, which fixation method do you recommend we use (PFA, paraformaldehyde, other)?

Verified Customer

Verified customer

Asked: 2019-01-29

Answer

It shows on the product datasheet, A06453 anti-Scn4b antibody as been validated on WB. It is best to use PFA for fixation because it has better tissue penetration ability. PFA needs to be prepared fresh before use. Long term stored PFA turns into formalin, as the PFA molecules congregate and become formalin.

Boster Scientific Support

Answered: 2019-01-29

Order DetailsPrice
A06453

100uL

$399

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