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We validate the specificity of these antibodies to SF3B4 by testing them on tissues known to express SF3B4 positively and negatively. Browse below to find the SF3B4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.
If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.
Facts about Splicing factor 3B subunit 4.
Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex.
Hsh49; pre-mRNA splicing factor SF3b 49 kDa subunit; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SAP 49; SAP49MGC10828; SF3b49; SF3b50; spliceosomal protein; spliceosome-associated protein (U2 snRNP); Spliceosome-associated protein 49; splicing factor 3B subunit 4; splicing factor 3b, subunit 4, 49kD; splicing factor 3b, subunit 4, 49kDa
|Sequence:||1; NC_000001.11 (149923317..149927803, complement)|
If you're planning to get the Boster Bio SF3B4 marker for your research, you're probably wondering how to use it. This article will help you learn how to use the SF3B4 markers. Read on to learn more! Boster Bio SF3B4 markers can make your research more valuable!
Recent immunohistochemical staining revealed that SF3B4 protein expression was reduced in pancreatic tumor tissue sections. This finding indicates that SF3B4 might play a role in pancreatic cancer. These results were consistent as SF3B4 increased regulation significantly inhibited cell movement. Seven paired specimens showed a decrease of SF3B4 protein levels.
A recent study has revealed that the SF3B4 protein regulates the splicing of pre-mRNA. As the role of splicing in the formation of mature and functional mRNA, SF3B4 is essential for proper splicing of the pre-mRNA. However, SF3B4 is not yet identified as the target gene. RNA-seq was done to determine if it regulates other splicing. rMAT analysis showed that intron 8 of RAD52 remained after SF3B4 knockdown in OC cells.
Many studies have looked at the biological function of SF3B4 cells in pancreatic carcinoma cells. RNAi lentiviruses with SF3B4 sequences were infected with pancreatic cancer cells. A control group was infected with the empty pCDH virus. The cells were not resistant to puromycin. The SF3B4 lentiviral vector was used for transfection of pancreatic cancer cells. Crystal violet assay was used to measure cell growth. Overexpression of SF3B4 reduced colony counts in OC cell lines.
SF3B4 is known to regulate 92 proteins-coding genes as well as two abnormal splicing events within ESCC. Functional enrichment analysis suggests that SF3B4's downstream targets may play a role in nuclear factor kB processes and cell-cell junction. SF3B4 could be used as a versatile marker to further research. Its discoveries could lead to improved understanding of human diseases.
Further research is required to understand the biological function of SF3B4 in human cancers. Its effect on STAT3 signaling which is involved in the progression of cancer is not fully understood. The results of this study indicate that the protein is expressed by pancreatic cancer cells, and thus offer a promising therapeutic strategy to treat the tumors. All the study authors stated that they had no competing interests. The National Natural Science Foundation of China supported the study.
Although SF3b4 has been implicated with the transcriptional process in metazoans, it was not discovered in humans. It was found that SF3b4 interacts directly with Pol II subunits via its RRM2domain. Consequently, SF3b4 has great potential to be used in genetic research. Its involvement in pre-mRNA processing could shed light on human disease.
The SF3B4 proteins also bind p180/RRBP1, which is essential for high-rate protein synthesis in the ER. The p180-associated ribosomes are unique in their ability to selectively increase translation. SF3b4 also plays a critical role in translation control. As mentioned previously, a SF3B4-related gene mutation could lead to a phenotypical disease called Nager syndrome. It may also affect bone morphogenesis and the production of collagen.
The SF3B4 gene, a novel genetic marker, has been identified as a promising target for drug development. It is a member in the E2 subfamily and is an important regulator of cellular metabolism. New therapies have been developed to treat this disorder. This has already led some breakthroughs. Boster's technology for gene silencing has been hailed for its high affinity and reproducibility.
AS regulation relies on the ribonucleoprotein SF3B4 genes. Mutations can lead to reduced SF3B4 synthesis and exon skipping. Overexpression of this gene promotes mis-splicing of Kruppel-like factor 4, a protein involved in tumorigenesis. HCC may result from a mutation in SF3B4.
Other components of SF3b are involved in splicing. It is involved in the assembly the 'B and 'C complexes, for example. It has also been implicated in the assembly of 'A' complexes. It isn't known what function it performs. Currently, research is underway in order to determine if SF3B4 levels are associated with certain types of diseases.
Numerous other pathological conditions have been linked to the SF3B4 gene, and its cognate receptor. SF3b3 is linked to brain injuries and liver damage, so it could play a role when cancer cells are detected. It acts as a signal molecular for the reprogramming dead cells. For more information, please contact technical support. They will be glad to answer any questions.
Instructions are given by the SF3B4 genes for the production and use of the SAP49 gene. This protein is part of the spliceosome, which is responsible to process messenger RNA (mRNA). The spliceosomes eliminate the introns from mRNA molecules to produce proteins. In addition, the SAP49 gene has been implicated in the bone morphogenic protein pathway, which controls various cellular processes and regulates the growth and maturation of bone cells.
The SF3B4 marker can be used in research on recombinant AV Vector Transduction. It has been used for identifying transduction inhibitors in a number of cellular processes such as tumor growth and inflammation. After infection, this protein interacts directly with viral capsids. The SF3B4 gene markers have many applications and are still expanding.
Studies have shown that SF3B4 has survival-related effect on ESCC. As it regulates AS in various cancers, it was found to be significantly differentially expressed in ESCC. Researchers found that patients with lower SF3B4 levels lived longer than those who had higher levels. Its RI event has the lowest p-value, suggesting that SF3B4 is a valuable tool in predicting tumor survival.