SF3B4 Antibodies

AND SF3B4 ELISA kits, SF3B4 Proteins

Many biological assays use antibodies to detect SF3B4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SF3B4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SF3B4 antibodies...

We validate the specificity of these antibodies to SF3B4 by testing them on tissues known to express SF3B4 positively and negatively. Browse below to find the SF3B4 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SF3B4? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SF3B4 Western Blot Guide

SF3B4 Infographic by Boster Bio

All SF3B4 Products

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Product

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Specificity

Applications

Price

Anti-SF3B4 Antibody Picoband®

Western blot analysis of SF3B4 using anti-SF3B4 antibody (A06414-1)

Human, Mouse, Rat

$370
Cat # A06414-1
100 μg/vial

Anti-Zebrafish SF3B4 Antibody Picoband®

Western blot analysis of SF3B4 using anti-SF3B4 antibody (AZQ6NWB3)

Zebrafish

$470
Cat # AZQ6NWB3
100 μg/vial

SF3B4 Overview

Facts about Splicing factor 3B subunit 4.

SF3B4 3D structure. Source: alphafold

Splicing factor 3B subunit 4 (SF3B4)

Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA.

Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA (PubMed:12234937). May also be involved in the assembly of the 'E' complex.

Gene Information

Human
Gene Name:	SF3B4
Uniprot:	Q15427
Entrez:	10262

Family

Belongs to:

SF3B4 family

Alternative Names

Hsh49; pre-mRNA splicing factor SF3b 49 kDa subunit; Pre-mRNA-splicing factor SF3b 49 kDa subunit; SAP 49; SAP49MGC10828; SF3b49; SF3b50; spliceosomal protein; spliceosome-associated protein (U2 snRNP); Spliceosome-associated protein 49; splicing factor 3B subunit 4; splicing factor 3b, subunit 4, 49kD; splicing factor 3b, subunit 4, 49kDa

Molecular Weight

Mass (kDA):
44.386 kDA

Genomic Context


Human

Location:	1q21.2
Sequence:	1; NC_000001.11 (149923317..149927803, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Immunologic Deficiency Syndromes
Neoplasms
Hiv Infections
Limb Deformities, Congenital
Malignant Neoplasm Of Gastrointestinal Tract
Burkitt Lymphoma
Leukemogenesis
Juvenile Polyposis Syndrome
Malignant Neoplasm Of Breast
Nager Syndrome
Acute Lymphocytic Leukemia

Dysostoses
Sarcoma
Unbalanced Translocation
Haploinsufficiency
Mandibulofacial Dysostosis
Leukemia
Polyposis

Interacting Proteins

BAG3
BAIAP2
BCAS2
CWF19L2
EFTUD2

FRK
GRB2
HNRNPUL1
HSPB7
MAPK9

METTL17
NCK2
NUB1
PPP1R16B
PRPF8

RBM10
RBM39
SEC24D
SF3B2
SS18L1

TCAF1
UBASH3A
WDR83
ZCCHC10

Pathways

Cell Cycle
Translation
Cell Cycle Arrest
Rna Splicing
Rna Stabilization
Ribosome Biogenesis
Mrna Splicing
G2 Phase

Cell Differentiation
Localization

PTMs

Methylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SF3B4

References

PMID: 7958871 by Champion-Arnaud P., et al. The prespliceosome components SAP 49 and SAP 145 interact in a complex implicated in tethering U2 snRNP to the branch site.

PMID: 10882114 by Das R., et al. Functional association of U2 snRNP with the ATP-independent spliceosomal complex E.