Transcription factor SOX-10 (SOX10)

Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination.

Once induced, MYRF cooperates with SOX10 to execute the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087).