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- Table of Contents
SOX10 Antibodies
AND SOX10 ELISA kits, SOX10 Proteins
Many biological assays use antibodies to detect SOX10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SOX10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SOX10 antibodies...
Designing a Western blot for SOX10? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SOX10 Western Blot GuideSOX10 Infographic by Boster Bio
All SOX10 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, ICC, WB
$370
Cat # M00758-1
100 μl
Cat # M00758-1
100 μl
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A00758-3
100 µg/vial
Cat # A00758-3
100 µg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$481
Cat # A00758
0.1 mg
Cat # A00758
0.1 mg
Human, Mouse, Rat
ELISA, IP, IF, IHC, WB
$146
Cat # M00758-3
20μL, 40μL, 100μL, 200μL
Cat # M00758-3
20μL, 40μL, 100μL, 200μL
SOX10 Overview
Facts about Transcription factor SOX-10.
Transcription factor SOX-10 (SOX10)
Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination.
Once induced, MYRF cooperates with SOX10 to execute the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087).
Gene Information
| Human | |
|---|---|
| Gene Name: | SOX10 |
| Uniprot: | P56693 |
| Entrez: | 6663 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
DOM; MGC15649; PCWH; SOX10; SRY (sex determining region Y)-box 10; SRY-related HMG-box gene 10; transcription factor SOX-10; WS4; WS4C; WS4mouse, human homolog of
Molecular Weight
Mass (kDA):
49.911 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 22q13.1 |
| Sequence: | 22; NC_000022.11 (37972312..37984555, complement) |
Tissue Specificity
Expressed in fetal brain and in adult brain, heart, small intestine and colon.
Subcellular Localizations
Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side.
Diseases
- Crest Syndrome
- Nervousness
- Hirschsprung Disease
- Waardenburg Syndrome
- Neoplasms
- Melanoma
- Complete Hearing Loss
- Waardenburg Syndrome, Type 4a
- Sensorineural Hearing Loss (disorder)
- Hypopigmentation Disorder
- Malignant Neoplasms
- Megacolon
Interacting Proteins
- NMI
- PAX3
- POU3F2
- SUMO1
- UBE2I
Pathways
- Myelination
- Pigmentation
- Cell Development
- Oligodendrocyte Differentiation
- Pathogenesis
- Cell Migration
- Cell Proliferation
- Cell Differentiation
- Neurogenesis
- Regeneration
- Oligodendrocyte Development
- System Development
- Nervous System Development
PTMs
- Phosphorylation
- Methylation
- Sumoylation
- Acetylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOX10
bosterbio.com/bosterbio-gene-info-cards/SOX10
References
PMID: 9462749 by Pingault V., et al. SOX10 mutations in patients with Waardenburg-Hirschsprung disease.
PMID: 9760192 by Pusch C., et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor.